Evidence map›Paper›PMID 35285410›Full record

ArticleCell cycle (Georgetown, Tex.)2022

KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.

Mingzi Li, Mingxun Zhang, Muling Chen, Jiantao Xiao, Xingyu Mu, Jingtao Peng, Jie Fan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. NK cells in renal cell carcinoma and its implications for CAR-NK therapy.Frontiers in cell and developmental biology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mingzi LiDepartment of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China.
Mingxun ZhangDepartment of Pathology, the First Affiliated Hospital of Ustc, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Muling ChenDepartment of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China.
Jiantao XiaoDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Xingyu MuDepartment of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China.
Jingtao PengDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jie FanDepartment of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China.
Shanghai First People's Hospital · CNUnion Hospital · CNUniversity of Science and Technology of China · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) is one of the most common and lethal types of urologic cancer. With low survival rates among patients in advanced stages of disease, and increasing rate of morbidity and mortality worldwide, novel therapeutic targets for ccRCC clinical intervention are necessary. In this study, we investigated the functional role of circZKSCAN1 in ccRCC progression. Our results suggested that circZKSCAN1 was abundantly expressed in ccRCC tumor tissues and cells. CircZKSCAN1 knockdown significantly inhibited cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition of renal cell carcinoma (RCC) cells, whereas potentiated Natural Killer (NK) cell-mediated cytotoxicity against RCC cells

Indexed as

Carcinoma, Renal CellKidney NeoplasmsMicroRNAsCarcinogenesisCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansIn Situ Hybridization, FluorescenceKruppel-Like Transcription FactorsProto-Oncogene Proteins c-pim-1RNA, CircularTranscription FactorsKLF2 protein, humanKruppel-Like Transcription FactorsMicroRNAsMIRN1294 microRNA, humanPIM1 protein, humanProto-Oncogene Proteins c-pim-1RNA, CircularTranscription FactorscircZKSCAN1clear cell renal cell carcinomaKLF2miR-1294PIM1

Identifiers

PMID35285410
PMCPMC9345621
OpenAlexW4220968584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.