Evidence map›Paper›PMID 35285393›Full record

ArticleRenal failure2022

Kt/V reach rate is associated with clinical outcome in incident peritoneal dialysis patients.

Shuang Liu, Lijie Zhang, Shuang Ma, Jing Xiao, Dong Liu, Rui Ding, Zhengyan Li, Zhanzheng Zhao

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Article in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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3 · Its place in the literature

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6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shuang LiuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-7441-3006
Lijie ZhangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shuang MaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jing XiaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Dong LiuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Rui DingDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhengyan LiDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhanzheng ZhaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0001-6079-1631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe urea clearance index (Kt/V) is an important index for predicting the clinical outcome of peritoneal dialysis (PD) patients, but it changes with time depending on the clinical condition. This study aimed to investigate the association between the Kt/V reach rate (defined as the percentage of Kt/V measurements that reached ≥ 1.70) and clinical outcome in incident PD patients.

methodsIn this retrospective cohort study, 210 patients were enrolled from the First Affiliated Hospital of Zhengzhou University from 1 January 2013 to 31 October 2019. The target Kt/V reach rate in the first year was applied as the predictor variable. Kaplan-Meier survival curves were drawn to evaluate differences in prognosis. The association between Kt/V reach rate and the composite clinical outcome (death or transfer to hemodialysis) was tested by Cox regression analysis.

resultsThe dialysis adequacy group (Kt/V reach rate 3/3 times) and the dialysis intermittent adequacy group (1/3 or 2/3 times) had significantly better clinical outcomes than the dialysis inadequacy group (0/3 times). There was no difference in clinical outcome between the lower-rate group (reach rate 1/3 times) and the higher-rate group (2/3 times). Compared with the dialysis inadequacy group, the dialysis intermittent adequacy group and dialysis adequacy group had significantly lower risks of the composite outcome (HR 0.487, 95% CI 0.244-0.971,

conclusionHigher Kt/V reach rates are associated with a better prognosis in incident PD patients.

Indexed as

Peritoneal DialysisUreaBlood Urea NitrogenHumansRenal DialysisRetrospective StudiesUreaclinical outcomeKt/Vperitoneal dialysisreach rate

Identifiers

PMID35285393
PMCPMC8928818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.