Evidence map›Paper›PMID 35285274›Full record

ArticleAmerican journal of physiology. Renal physiology2022

βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.

Yan Lu, David E Stec, Ruisheng Liu, Michael Ryan, Heather A Drummond

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Acid-sensing ion channel 2a assembles with epithelial NaThe Journal of biological chemistry · 2026
    Article
  3. Review
  4. Article
  5. Epithelial Na+ Channels, Immune Cells, and Salt.Annual review of physiology · 2025
    Review
  6. Article
  7. Epithelial NaComprehensive Physiology · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Yan LuDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David E StecDepartment of Physiology and Biophysics and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-8359-4008
Ruisheng LiuDepartment of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, Florida.ORCID 0000-0002-2220-1888
Michael RyanDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina.
Heather A DrummondDepartment of Physiology and Biophysics and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-7171-804X
University of Mississippi Medical Center · USUniversity of Alabama at Birmingham · USUniversity of South Carolina · USUniversity of South Florida · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Integrative Role of Bilirubin on ObesityR01DK121748 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI STEC, DAVID E · 2020 to 2023
$2.0M
NHLBI NIH HHS P01 HL051971NIDDK NIH HHS R01 DK121748NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

In independent studies, our laboratory has shown the importance of the degenerin proteins β-epithelial Na

Indexed as

KidneyMuscle, Smooth, VascularAnimalsArteriolesConstrictionMiceVasoconstrictionblood pressuredegenerinepithelial Na+ channelglomerular injurymyogenic

Identifiers

PMID35285274
PMCPMC8977180
OpenAlexW4220783590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.