Evidence map›Paper›PMID 35284969›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.

Katarina Sjögreen Gleisner, Nicolas Chouin, Pablo Minguez Gabina, Francesco Cicone, Silvano Gnesin, Caroline Stokke, Mark Konijnenberg, Marta Cremonesi, Frederik A Verburg, Peter Bernhardt and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 3 pooled it
31.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 3 syntheses or guidelines pooled it, 218 citations in OpenAlex.

  1. Guideline
  2. Joint EANM/SNMMI procedure guideline for the use ofEuropean journal of nuclear medicine and molecular imaging · 2023
    Guideline
  3. Joint EANM/SNMMI procedure guideline for the use ofEuropean journal of nuclear medicine and molecular imaging · 2023
    Guideline
  4. Pharmacokinetics and dosimetry of [Annals of nuclear medicine · 2025
    Trial
  5. Dosimetry of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  6. Trial
  7. Patient Survival and Its Relation to Tumor Absorbed Dose in [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  8. Dosimetry-Driven Personalization of Radiopharmaceutical Therapies: Evidence and Opportunities.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. PROQURE-I: a phase I study adding concurrent [European journal of nuclear medicine and molecular imaging · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 12 institutions in 9 countries.

Katarina Sjögreen GleisnerMedical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden. katarina.sjogreen_gleisner@med.lu.se.ORCID http://orcid.org/0000-0001-5664-8760
Nicolas ChouinUniversité de Nantes, CNRS, Inserm, Oniris, CRCINA, Nantes, France.
Pablo Minguez GabinaDepartment of Medical Physics and Radiation Protection, Gurutzeta-Cruces University Hospital/Biocruces Health Research Institute, Barakaldo, Spain.
Francesco CiconeDepartment of Experimental and Clinical Medicine, Neuroscience Research Centre, PET/RM Unit, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
Silvano GnesinInstitute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Caroline StokkeDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Mark KonijnenbergDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Marta CremonesiRadiation Research Unit, Department of Medical Imaging and Radiation Sciences, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Frederik A VerburgDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Peter BernhardtDepartment of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Uta EberleinDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Jonathan GearJoint department of Physics, Royal Marsden NHSFT and Institute of Cancer Research, Sutton, UK.
Centre National de la Recherche Scientifique · FRErasmus MC · NLInstitute of Cancer Research · GBIstituti di Ricovero e Cura a Carattere Scientifico · ITLund University · SEMagna Graecia University · ITOslo University Hospital · NORadboud University Nijmegen · NLSahlgrenska University Hospital · SEUniversitätsklinikum Würzburg · DEUniversity of Lausanne · CHUniversity of the Basque Country · ES

Funding

Cancerfonden 180747Cancerfonden 211754Pj01HFru Berta Kamprads Stiftelse FBKS-2020-13
6 · The paper itself

Abstract

The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular for the treatment of metastatic neuroendocrine tumours using ligands for somatostatin receptors and prostate adenocarcinoma with small-molecule PSMA-targeting ligands. This paper provides an overview of reported dosimetry data for these therapies and summarises current knowledge about radiation-induced side effects on normal tissues and dose-effect relationships for tumours. Dosimetry methods and data are summarised for kidneys, bone marrow, salivary glands, lacrimal glands, pituitary glands, tumours, and the skin in case of radiopharmaceutical extravasation. Where applicable, taking into account the present status of the field and recent evidence in the literature, guidance is provided. The purpose of these recommendations is to encourage the practice of patient-specific dosimetry in therapy with 177Lu-labelled compounds. The proposed methods should be within the scope of centres offering therapy with 177Lu-labelled ligands for somatostatin receptors or small-molecule PSMA.

Indexed as

Radiation InjuriesReceptors, SomatostatinHumansLigandsLutetiumMaleProstate-Specific AntigenRadioisotopesRadiopharmaceuticalsSomatostatinLigandsLutetiumLutetium-177Prostate-Specific AntigenRadioisotopesRadiopharmaceuticalsReceptors, SomatostatinSomatostatinDosimetryLutetium-177NeuroendocrineProstate adenocarcinomaPSMA-targeting ligandsSomatostatin-receptor ligands

Identifiers

PMID35284969
PMCPMC9015994
OpenAlexW4221014004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.