Evidence map›Paper›PMID 35284826›Full record

ArticleFunction (Oxford, England)2022

SARS-CoV-2 S Protein Subunit 1 Elicits Ca

Julia V Gerasimenko, Ole H Petersen, Oleg V Gerasimenko

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  9. Article
  10. The role of CaCell calcium · 2023
    Review
  11. The 2022 George E Palade Medal Lecture: Toxic CaPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Julia V GerasimenkoSchool of Biosciences, Sir Martin Evans Building, Cardiff University, Wales CF10 3AX, UK.ORCID 0000-0002-2262-2543
Ole H PetersenSchool of Biosciences, Sir Martin Evans Building, Cardiff University, Wales CF10 3AX, UK.ORCID 0000-0002-6998-0380
Oleg V GerasimenkoSchool of Biosciences, Sir Martin Evans Building, Cardiff University, Wales CF10 3AX, UK.ORCID 0000-0003-2573-8258
Cardiff University · GB

Funding

Medical Research Council G19/22/2Medical Research Council MR/J002771/1
6 · The paper itself

Abstract

The S protein subunit 1 (S1) of SARS-CoV-2 is known to be responsible for the binding of the virus to host cell receptors, but the initial intracellular signalling steps following receptor activation of cells in the exocrine pancreas are unknown. Using an intact live mouse pancreatic lobule preparation, we observed that S1 elicited Ca

Indexed as

COVID-19PancreatitisAcute DiseaseAnimalsBenzamidesCalcium SignalingHumansMacrophagesMicePancreatic Stellate CellsPyrazinesSARS-CoV-2Spike Glycoprotein, CoronavirusBenzamidesPyrazinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2zegocractincalcium signallingCM4620IL-18BPinterleukin-18ORAI1 CRAC channelspancreatic macrophagespancreatic stellate cellsS1 spike proteinSARS-COV-2

Identifiers

PMID35284826
PMCPMC8903325
OpenAlexW4210546996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.