ArticleBio-protocol2022
Large-scale Analysis of Sleep in Zebrafish.
Article in Bio-protocol, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.iScience · 2026Article
- Cross-trait clustering of sub-threshold sleep genetic signals identifies EGR2 as a conserved regulator of sleep.bioRxiv : the preprint server for biology · 2026Article
- Melatonin promotes sleep by suppressing responses to visual stimuli via MT1 receptors.Current biology : CB · 2026Article
- Time-Resolved Proteomic Analysis in Zebrafish Using Bioorthogonal Noncanonical Amino Acid Tagging.Journal of proteome research · 2026Article
- Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep.bioRxiv : the preprint server for biology · 2026Article
- Zebrafish sleep displays distinct sub-states.iScience · 2026Article
- Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.Nature communications · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Zebrafish as a translational filter for natural sleep modulators.Frontiers in nutrition · 2026Review
- The influence of sleep disruption on learning and memory in fish.Journal of sleep research · 2025Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- Zebrafish sleep displays distinct sub-states.bioRxiv : the preprint server for biology · 2025Article
- Article
- Measuring Sleep and Activity Patterns in Adult Zebrafish.Bio-protocol · 2024Article
- Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish.Frontiers in neuroscience · 2024Article
- Pleiotropic effects of a high confidence Autism Spectrum Disorder gene,Neurobiology of sleep and circadian rhythms · 2023Article
- Identification of nicotine-seeking and avoiding larval zebrafish using a new three-choice behavioral assay.Frontiers in molecular neuroscience · 2023Article
- Knockout ofInternational journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Over the past decade, zebrafish have emerged as a powerful model for the study of vertebrate sleep and wake behaviors. Experimental evidence has demonstrated behavioral, anatomical, genetic, and pharmacological conservation of sleep between zebrafish and mammals, suggesting that discoveries in zebrafish can inform our understanding of mammalian sleep. Here, we describe a protocol for performing sleep behavioral experiments in larval zebrafish, using a high-throughput video tracking system. We explain how to set up a sleep behavioral experiment and provide guidelines on how to analyze the data. Using this protocol, a typical experiment can be completed in less than five days, and this method provides a scalable platform to perform genetic and pharmacological screens in a simple and cost-effective vertebrate model. By combining high-throughput behavioral assays with several advantageous features of zebrafish, this model system provides new opportunities to make discoveries that clarify the genetic and neurological mechanisms that regulate sleep.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.