ArticleAnnals of translational medicine2022
Assessing the impact of monocular deprivation on visual evoked potentials, behavior, and visual plasticity in juvenile mice.
Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Association of Altered V1-M2 Neuronal Activation with Balance and Coordination Deficits in a Corneal Alkali Burn Mouse Model of Visual Impairment.Brain sciences · 2026Article
- Environmental Enrichment Enhances Visual Function in Adult Amblyopia: Association With miR-132/HDAC3 Regulation.Neural plasticity · 2026Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The physiological mechanisms which underlie amblyopia are predicted using animal models which assess the impact of amblyogenic factors on visual function. This study used monocular-deprived mice as an amblyopic model to assess visual function by flash visual evoked potentials (fVEP), behavioral assessment, and visual plasticity. Methods: A total of 294 C57BL/6J mice (both genders) were used in this study. The mice were divided into the normal control (NC) group and monocular deprivation (MD) group. After mice were anesthetized with pentobarbital, fVEP was recorded. Long-term potentiation (LTP) was recorded from primary visual cortex slices. Behavioral assessment of visual function was performed using a visual water trapezoidal-shaped pool with a release chute, a hidden platform, and a middle divider. Results: All fVEP results showed that N1 waves and P2 waves were repeatable and N1-P2 amplitude was the most stable indicator. The amplitude of N1-P2 of MD eyes was significantly lower than that of non-deprived eyes or NC eyes. LTP failed to be induced in the visual cortex V1 area corresponding to deprived eyes in the MD group but could be induced successfully in the visual cortex V1 area corresponding to non-deprived eyes in the MD group. Behavioral vision testing also showed a longer time to reach the platform in MD mice compared to NC mice. The correlation coefficient suggested that LTP is the better indicator for visual impairment. Conclusions: The fVEP can be utilized as an index of amblyopic changes in mice, which correlates well with behavioral results.
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