Evidence map›Paper›PMID 35284425›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Impact of the Amyotrophic Lateral Sclerosis Disease on the Biomechanical Properties and Oxidative Stress Metabolism of the Lung Tissue Correlated With the Human Mutant SOD1

Duygu Aydemir, Anjum Naeem Malik, Ibrahim Kulac, Ayse Nazli Basak, Ismail Lazoglu, Nuriye Nuray Ulusu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Systemic brain-body metabolic coupling patterns in amyotrophic lateral sclerosis: a whole-body [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. Silicosis: from pathogenesis to therapeutics.Frontiers in pharmacology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Duygu AydemirDepartment of Medical Biochemistry, School of Medicine, Koc University, Istanbul, Turkey.
Anjum Naeem MalikManufacturing and Automation Research Center, Department of Mechanical Engineering, Koc University, Istanbul, Turkey.
Ibrahim KulacDepartment of Pathology, Koc University School of Medicine, Istanbul, Turkey.
Ayse Nazli BasakSuna and İnan Kirac Foundation, Neurodegeneration Research Laboratory, NDAL-KUTTAM, School of Medicine, Koc University, Istanbul, Turkey.
Ismail LazogluManufacturing and Automation Research Center, Department of Mechanical Engineering, Koc University, Istanbul, Turkey.
Nuriye Nuray UlusuDepartment of Medical Biochemistry, School of Medicine, Koc University, Istanbul, Turkey.
Koç University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, and ALS incidence is increasing worldwide. Patients with ALS have respiratory failure at the disease's end stages, leading to death; thus, the lung is one of the most affected organs during disease progression. Tissue stiffness increases in various lung diseases because of impaired extracellular matrix (ECM) homeostasis leading to tissue damage and dysfunction at the end. According to the literature, oxidative stress is the major contributor to ECM dysregulation, and mutant protein accumulation in ALS have been reported as causative to tissue damage and oxidative stress. In this study, we used SOD1

Indexed as

ALSbiomechanical testoxidative stressSOD1stiffness

Identifiers

PMID35284425
PMCPMC8914018
OpenAlexW4214717398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.