ArticleQuantitative imaging in medicine and surgery2022
Abnormal interhemispheric functional connectivity in patients with primary dysmenorrhea: a resting-state functional MRI study.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Regional homogeneity alterations reflect pain and emotional dysregulation in adenomyosis.Annals of medicine · 2026Article
- Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026Review
- Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting-State fMRI Study.Brain and behavior · 2025Article
- The neurobiology of plant-based therapeutics in women's reproductive health: mechanisms, efficacy, and clinical translation.Frontiers in nutrition · 2025Review
- Multimodal transformer graph convolution attention isomorphism network (MTCGAIN): a novel deep network for detection of insomnia disorder.Quantitative imaging in medicine and surgery · 2024Article
- Abnormal Topological Organization of Human Brain Connectome in Primary Dysmenorrhea Patients Using Graph Theoretical Analysis.Journal of pain research · 2024Article
- Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa.Quantitative imaging in medicine and surgery · 2023Article
- Changes in brain structure and related functional connectivity during menstruation in women with primary dysmenorrhea.Quantitative imaging in medicine and surgery · 2023Article
- Revealing the Central Mechanism of Acupuncture for Primary Dysmenorrhea Based on Neuroimaging: A Narrative Review.Pain research & management · 2023Review
- Bibliometric Analysis of Global Research Landscape and Hotspots on Dysmenorrhea: Where are We Now?Journal of pain research · 2023Article
- Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity.Frontiers in neuroscience · 2022Article
- Disrupted Spontaneous Neural Activity and Its Interaction With Pain and Emotion in Temporomandibular Disorders.Frontiers in neuroscience · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuroimaging studies have confirmed that functional connectivity (FC) disruption of pain-related brain networks may contribute to the cerebral pathophysiology of primary dysmenorrhea (PDM). However, it remains unclear whether FC of symmetrical regions of bilateral hemispheres associated with PDM is abnormal. This functional MRI study aimed to explore the changes of voxel-mirrored homotopic connectivity (VMHC) and seed-based FC in patients with PDM. Methods: A cohort comprising patients with PDM (n=35) and healthy controls (HCs) (n=41) underwent resting-state functional MRI scans during their menstrual phase. Interhemispheric FC was compared between the two groups using VMHC analysis. Brain areas with significant group differences in VMHC were selected as seed regions for FC analysis. Correlation analysis was also conducted to examine the relationship between abnormal connectivity of brain regions and clinical measures of pain and anxiety. Results: Compared with healthy individuals, patients with PDM showed significantly enhanced VMHC in the bilateral orbital part of the superior frontal gyrus and the bilateral middle frontal gyrus. Subsequent seed-based FC analysis showed enhanced connectivity between the aforementioned areas and pain-related brain structures. Hyperconnectivity between the left middle frontal gyrus and the right cingulate gyrus in patients was negatively correlated with an increase in the visual analogue score (VAS) for pain (r=-0.341, P<0.05). Conclusions: Our findings indicate that ongoing dysmenorrhea is accompanied by abnormal interhemispheric functional coordination and enhanced connectivity in pain-related regions, attention networks, and the reward system. These findings may provide a novel perspective on the central mechanism of pain caused by PDM.
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