Evidence map›Paper›PMID 35284229›Full record

ArticleIDCases2022

Hemophagocytic lymphohistiocytosis presenting in a patient with human immunodeficiency virus and reactivated Hepatitis B infection.

David T Chen, Imari Patel, Stephanie Cabral, Sai Chintalapati, Aaron Iddings, Devang Patel

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David T ChenDepartment of Internal Medicine, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD, USA.
Imari PatelDepartment of Internal Medicine, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD, USA.
Stephanie CabralDepartment of Internal Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, USA.
Sai ChintalapatiDepartment of Infectious Diseases, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD, USA.
Aaron IddingsDepartment of Hematology/Oncology, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD, USA.
Devang PatelDepartment of Infectious Diseases, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome of inappropriate immune activation which can present at any age and is commonly associated with other conditions of either excessive or impaired immune response, such as malignancy, infection, autoimmunity or immunodeficiency. In cases associated with human immunodeficiency virus (HIV) infection, an additional trigger such as acute infection or malignancy is frequently identified. We report a case of HLH presenting in a patient with uncontrolled HIV and reactivated hepatitis B infection, which to our knowledge has only been reported once before. Given challenges with diagnosis and its life-threatening course, HLH is an important consideration especially in critically ill patients with underlying HIV and nonspecific presentations such as fevers, cytopenias and encephalopathy.

Indexed as

Hemophagocytic lymphohistiocytosisHepatitis BHuman immunodeficiency

Identifiers

PMID35284229
PMCPMC8914532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.