Evidence map›Paper›PMID 35284190›Full record

ArticleBiomedical optics express2022

Polarization enhanced laparoscope for improved visualization of tissue structural changes associated with peritoneal cancer metastasis.

Robert M Trout, Einstein Gnanatheepam, Ahmed Gado, Christopher Reik, Jessica C Ramella-Roman, Martin Hunter, Thomas Schnelldorfer, Irene Georgakoudi

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Robert M TroutDepartment of Biomedical Engineering, Tufts University, 200 College Ave, Medford, MA 01255, USA.
Einstein GnanatheepamDepartment of Biomedical Engineering, Tufts University, 200 College Ave, Medford, MA 01255, USA.ORCID https://orcid.org/0000-0002-6710-4336
Ahmed GadoDepartment of Biomedical Engineering, Tufts University, 200 College Ave, Medford, MA 01255, USA.
Christopher ReikDepartment of Biomedical Engineering, Tufts University, 200 College Ave, Medford, MA 01255, USA.
Jessica C Ramella-RomanDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.
Martin HunterDepartment of Biomedical Engineering, University of Massachusetts at Amherst, Amherst, MA, USA.
Thomas SchnelldorferDepartment of Biomedical Engineering, Tufts University, 200 College Ave, Medford, MA 01255, USA.
Irene GeorgakoudiDepartment of Biomedical Engineering, Tufts University, 200 College Ave, Medford, MA 01255, USA.ORCID https://orcid.org/0000-0002-0049-6697
Tufts University · USFlorida International University · USUniversity of Massachusetts Amherst · US

Funding

Acquisition of Leica confocal/multiphoton microscopeS10OD021624 · OD · TUFTS UNIVERSITY MEDFORD · PI GEORGAKOUDI, IRENE · 2016 to 2016
$600k
Polarized Light Laparascopy of Occult Cancer MetastasesR21EB023498 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI GEORGAKOUDI, IRENE, SCHNELLDORFER, THOMAS · 2017 to 2018
$446k
NIBIB NIH HHS R21 EB023498NIH HHS S10 OD021624
6 · The paper itself

Abstract

A polarization enhanced laparoscopy (PEL) imaging system was developed to examine the feasibility of utilizing PEL to augment conventional white light laparoscopy (WLL) in the visualization of peritoneal cancer metastases. The system includes a modified tip to illuminate tissue with linearly polarized light and elements in the detection path enabling recording of corresponding images linearly co- and cross-polarized relative to the incident light. WLL and PEL images from optical tissue phantoms with features of distinct scattering cross-section confirm the enhanced sensitivity of PEL to such characteristics. Additional comparisons based on images acquired from collagen gels with different levels of fiber alignment highlight another source of PEL contrast. Finally, PEL and WLL images of ex vivo human tissue illustrate the potential of PEL to improve visualization of cancerous tissue surrounded by healthy peritoneum. Given the simplicity of the approach and its potential for seamless integration with current clinical practice, our results provide motivation for clinical translation.

Identifiers

PMID35284190
PMCPMC8884200
OpenAlexW4200285344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.