ArticleBiomedical optics express2022
Multiple-scattering suppressive refractive index tomography for the label-free quantitative assessment of multicellular spheroids.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.Nature biomedical engineering · 2026Review
- Inverse scattering in biological samples via beam propagation.Science advances · 2026Article
- Label-Free Machine Learning Prediction of Chemotherapy on Tumor Spheroids Using a Microfluidics Droplet Platform.Small science · 2025Article
- Bidirectional in-silico clearing approach for deep refractive-index tomography using a sparsely sampled transmission matrix.Biomedical optics express · 2024Article
- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation.Light, science & applications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Refractive index (RI) tomography is a quantitative tomographic technique used to visualize the intrinsic contrast of unlabeled biological samples. Conventional RI reconstruction algorithms are based on weak-scattering approximation, such as the Born or Rytov approximation. Although these linear algorithms are computationally efficient, they are invalid when the fields are strongly distorted by multiple scattering (MS) of specimens. Herein, we propose an approach to reconstruct the RI distributions of MS objects even under weak-scattering approximation using an MS-suppressive operation. The operation converts the distorted fields into MS-suppressed fields, where weak-scattering approximation is applicable. Using this approach, we reconstructed a whole multicellular spheroid and successfully visualized its internal subcellular structures. Our work facilitates the realization of RI tomography of MS specimens and label-free quantitative analysis of 3D multicellular specimens.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.