ArticleBiomedical optics express2022
Ex vivo hypercellular parathyroid gland differentiation using dynamic optical contrast imaging (DOCI).
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- A Novel Imaging Technique to Identify Vocal Fold Scar Formation.Laryngoscope investigative otolaryngology · 2026Article
- Parathyroid autotransplantation: a phase-based framework for surgical decision-making.Frontiers in endocrinology · 2026Review
- Machine-learning-based tumor segmentation and classification using dynamic optical contrast imaging for thyroid cancer.Biophotonics discovery · 2026Article
- Article
- The research progress of label-free optical imaging technology in intraoperative real-time navigation of parathyroid glands.Lasers in medical science · 2025Review
- Cell-Based Outer Vocal Fold Replacement Both Treats and Prevents Vocal Fold Scarring in Rabbits.The Laryngoscope · 2024Article
- Label-free, real-time detection of perineural invasion and cancer margins in a murine model of head and neck cancer surgery.Scientific reports · 2022Article
- Intraoperative In Vivo Imaging Modalities in Head and Neck Cancer Surgical Margin Delineation: A Systematic Review.Cancers · 2022Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Primary hyperparathyroidism, often caused by a single adenoma (80-85%) or four-gland hyperplasia (10-15%), can lead to elevated parathyroid hormone (PTH) levels and resultant hypercalcemia. Surgical excision of offending lesions is the standard of care, as the removal of pathologic adenomas reduces PTH and calcium values to baseline. The small size, variable location, and indistinct external features of parathyroid glands can make their identification quite challenging intraoperatively. Our group has developed the dynamic optical contrast imaging (DOCI) technique, a novel realization of dynamic temporally dependent measurements of tissue autofluorescence. In this study, we evaluated the efficacy of using the DOCI technique and normalized steady-state fluorescence intensity data for differentiating types of human parathyroid and thyroid tissues. We demonstrate that the DOCI technique has the capability to distinguish normal parathyroid tissue from diseased parathyroid glands as well as from adjacent healthy thyroid and adipose tissue across 8 different spectral channels between 405nm-600nm (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.