ReviewFrontiers in physiology2022
Updated Review on Ozone Therapy in Pain Medicine.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness and Cost-effectiveness of Ozone Treatment in Patients With Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (OzoParQT)
Gene and Molecular Pathway Characterization of the Response to Ozone Treatment in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Radio-chemotherapy
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of ozone therapy in dentistry with approach of healing, pain management, and therapeutic outcomes: a systematic review of clinical trials.BMC oral health · 2025Pooled it
- Nonpharmacological Complementary Interventions for the Management of Pain after Third Molar Surgery: An Umbrella Review of Current Meta-Analyses.Pain research & management · 2022Pooled it
- Trial
- Experimental evidence for the beneficial effects of low-concentration ozone.Medical gas research · 2027Review
- Ozone Therapy as a Redox-Modulating Strategy in Degenerative Musculoskeletal Diseases: A Clinical-Mechanistic Review.Journal of clinical medicine · 2026Review
- Efficacy of Oxygen-Ozone Therapy for Shoulder Disorders: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Comparison of HDL-Associated Antioxidant Activities and Anti-Inflammatory Effect Between Ozonated Sunflower Oil (OSO) and Ozonated Olive Oil (OOO) Under Carboxymethyllysine-Induced Acute Phase in Zebrafish Adults and Embryos.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of Oxygen-Ozone Therapy and Physiotherapy on Functioning in Patients with Chronic Non-Specific Neck Pain: A Prospective Double-Arm Pilot Study.Journal of functional morphology and kinesiology · 2026Article
- Modified Ozone-Mediated Neurolysis for Resistant Hypertension in a Patient With Bilateral Renal Artery Stenosis.JACC. Case reports · 2026Article
- Low ozone concentrations promoteEuropean journal of histochemistry : EJH · 2026Article
- Clinical Outcomes of Intra-Articular Ozone Injections in Hip Osteoarthritis: A Retrospective Study Comparing Different Injection Frequencies.Journal of clinical medicine · 2026Article
- Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes.Animals : an open access journal from MDPI · 2026Article
- Combined High-Voltage Long-Duration Pulsed Radiofrequency and Ozone Therapy in the Treatment of Pudendal Neuralgia: A Retrospective Case Series.Journal of pain research · 2026Article
- CT-guided spinal nerve root adhesiolysis for refractory atypical symptoms in cervical disc herniation: a retrospective cohort study.Frontiers in medicine · 2026Article
- CT-guided transforaminal versus C-arm-guided intradiscal ozone injection for cervical disc herniation: a comparative cohort study.Frontiers in medicine · 2026Article
- Predictive Value of Epidural Gas Spread Pattern Following Transforaminal Ozone Injection for Clinical Outcomes in Cervical Radiculopathy: A Prospective Cohort Study.Journal of pain research · 2026Article
- Ozone therapy in femoral head necrosis: a perspective on biomarker-guided treatment rationalization and mechanistic exploration.Frontiers in medicine · 2026Article
- Efficacy of fluoroscopy-guided transforaminal epidural steroid injection with or without ozone in patients with lumbar radiculopathy: A single-center study.Turkish journal of physical medicine and rehabilitation · 2025Article
- Oxygen-Ozone Therapy in Tendinopathy Management: A Comprehensive Review.Journal of personalized medicine · 2025Review
- Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy.Nanomaterials (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of medical ozone in the treatment of chronic pain is progressively expanding in Spain and today it is used both in public and private medical centers. However, there is a great lack of knowledge about this technology not only in primary care but also in medical specialties. Although its biochemical bases are well determined and there are various systematic reviews and meta-analyses in the literature that justify its use in pain medicine, some professionals still are prejudiced against it. The evidence level of using medical ozone according SIGN (Scotish Intercollegiate Guideline Network) criteria is similar or superior to most of the techniques used in a Pain Unit. In this paper, we have done a review on ozone therapy in pain medicine, compiling the evidence published about it.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.