ArticleSaudi journal of medicine & medical sciences
External Validation of 4C ISARIC Mortality Score in Critically ill COVID-19 Patients from Saudi Arabia.
Article in Saudi journal of medicine & medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Prognostic models in COVID-19 infection that predict severity: a systematic review.European journal of epidemiology · 2023Pooled it
- Tracking the evolution of biomarker efficacy in SARS-CoV-2: a global meta-analyses series.Respiratory research · 2026Article
- Severity Scores in SARS-CoV-2 Infection-A Comprehensive Bibliometric Review and Visualization Analysis.Epidemiologia (Basel, Switzerland) · 2026Review
- Predictive accuracy of 4C Mortality Score and Acute Physiology and Chronic Health Evaluation scores for mortality in COVID-19 patients admitted to intensive care unit.World journal of critical care medicine · 2025Article
- 4C mortality score and COVID-19 mortality risk score: an analysis in four different age groups of an Italian population.Internal and emergency medicine · 2024Article
- External validation of the ISARIC 4C Mortality Score to predict in-hospital mortality among patients with COVID-19 in a Canadian intensive care unit: a single-centre historical cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
- Article
- Utility of the 4C ISARIC mortality score in hospitalized COVID-19 patients at a large tertiary Saudi Arabian center.Multidisciplinary respiratory medicine · 2023Article
- Assessment of risk scores to predict mortality of COVID-19 patients admitted to the intensive care unit.Frontiers in medicine · 2023Article
- Stratification of patients admitted for SARS-CoV2 infection: prognostic scores in the first and second wave of the pandemic.Internal and emergency medicine · 2022Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Background: ISARIC mortality score is a risk stratification tool that helps predict the in-hospital mortality of COVID-19 patients. However, this tool was developed and validated in a British population, and thus, the external validation of this tool in local populations is important. Objectives: External validation of the ISARIC mortality score in COVID-19 patients from a large Saudi Arabian intensive care unit (ICU). Methods: This is a retrospective study that included all adult patients with COVID-19 admitted to the ICU of King Saud Medical City, Riyadh, Saudi Arabia, from March 2020 to June 2021. Patients who were pregnant or had pulmonary tuberculosis/human immunodeficiency virus were excluded along with patients with missing variables. Data were collected to calculate the ISARIC mortality score and then fitting receiver operator characteristic curve against patients' outcome. Results: A total of 1493 critically ill COVID-19 patients were included. The mortality was 38%, the area under the curve of the score was 0.81 (95% confidence interval [CI]: 0.79-0.83, Conclusion: The ISARIC score was found to have excellent predictive ability for mortality in critically ill COVID-19 patients in our Saudi Arabian cohort. A cutoff score of >9 was the optimal criterion.
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