ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2022
Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 12 citations in OpenAlex.
- Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the NematodeCells · 2025Review
- The intron binding protein EMB-4 is an opposite regulator of cold and high temperature tolerance inPNAS nexus · 2024Article
- Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B.Scientific reports · 2024Article
- Cold Tolerance in the Nematode Caenorhabditis elegans.Advances in experimental medicine and biology · 2024Review
- Head-tail-head neural wiring underlies gut fat storage inProceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Many organisms can survive and proliferate in changing environmental temperatures. Here, we introduce a molecular physiological mechanism for cold tolerance and acclimation of the nematode Caenorhabditis elegans on the basis of previous reports and a new result. Three types of thermosensory neurons located in the head, ASJ, ASG, and ADL, regulate cold tolerance and acclimation. In ASJ, components of the light-signaling pathway are involved in thermosensation. In ASG, mechanoreceptor DEG-1 acts as thermoreceptor. In ADL, transient receptor potential channels are thermoreceptors; however, the presence of an additional unidentified thermoreceptor is also speculated. ADL thermoresponsivity is modulated by oxygen sensory signaling from URX oxygen sensory neurons via hub interneurons. ASJ releases insulin and steroid hormones that are received by the intestine, which results in lipid composition changing with cold tolerance. Additionally, the intestinal transcriptional alteration affects sperm functions, which in turn affects the thermosensitivity of ASJ; thus, the neuron-intestine-sperm-neuron tissue circuit is essential for cold tolerance.
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