Evidence map›Paper›PMID 35283261›Full record

ArticleContemporary clinical trials2022

The Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients (CLIP-OA) trial: Design and methods.

Brian C Focht, W Jack Rejeski, Kevin Hackshaw, Walter T Ambrosius, Erik Groessl, Zachary L Chaplow, Victoria R DeScenza, Jessica Bowman, Ciaran M Fairman, Beverly Nesbit and 5 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02835326 (The Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02835326 nacompletednot on this map

The Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients: CLIP-OA

TypeinterventionalSponsorOhio State UniversityRan2016 to 2022Enrolled227ConditionsOsteoarthritisArmsExercise and Dietary Weight Loss, Walk with Ease
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Brian C FochtKinesiology, Department of Human Sciences, The Ohio State University, USA. Electronic address: focht.10@osu.edu.
W Jack RejeskiDepartment of Health and Exercise Science, Wake Forest University, USA.
Kevin HackshawDepartment of Internal Medicine, University of Texas - Austin, USA.
Walter T AmbrosiusDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, USA.
Erik GroesslHealth Services Research Center, Herbert Wertheim School of Public Health University of California San Diego, USA.
Zachary L ChaplowKinesiology, Department of Human Sciences, The Ohio State University, USA.
Victoria R DeScenzaKinesiology, Department of Human Sciences, The Ohio State University, USA.
Jessica BowmanKinesiology, Department of Human Sciences, The Ohio State University, USA.
Ciaran M FairmanExercise Science Department, Arnold School of Public Health, University of South Carolina, USA.
Beverly NesbitDepartment of Health and Exercise Science, Wake Forest University, USA.
Kathryn DispennetteKinesiology, Department of Human Sciences, The Ohio State University, USA.
Xiaochen ZhangKinesiology, Department of Human Sciences, The Ohio State University, USA.
Marissa FowlerKinesiology, Department of Human Sciences, The Ohio State University, USA.
Marcy HaynamKinesiology, Department of Human Sciences, The Ohio State University, USA.
Stephanie HohnKinesiology, Department of Human Sciences, The Ohio State University, USA.
The Ohio State University · USWake Forest University · USThe University of Texas at Austin · USUniversity of California, San Diego · USUniversity of South Carolina · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Comprehensive Lifestyle Intervention Program for Knee Osteoarthritis Patients (CLIP-OA)R01AG050725 · NIA · OHIO STATE UNIVERSITY · PI FOCHT, BRIAN CARL · 2016 to 2020
$2.8M
Addressing Obesity to Reduce Cancer Risk and Health Disparities in Underserved PopulationsF99CA253745 · NCI · OHIO STATE UNIVERSITY · PI ZHANG, XIAOCHEN · 2020 to 2021
$86k
NCATS NIH HHS UL1 TR002733NCI NIH HHS F99 CA253745NIA NIH HHS R01 AG050725
6 · The paper itself

Abstract

Being overweight or obese is a primary modifiable risk factor that exacerbates disease progression and mobility disability in older knee osteoarthritis (OA) patients. Lifestyle interventions combining exercise with dietary weight loss (EX+DWL) yield meaningful improvements in mobility and weight loss that are superior to EX or DWL alone. Unfortunately, community access to practical, sustainable weight management interventions remains limited and places knee OA patients at increased risk of mobility disability. The Collaborative Lifestyle Intervention Program in Knee Osteoarthritis patients (CLIP-OA), was a two-arm, 18 month randomized-controlled, comparative effectiveness trial designed to contrast the effects of an evidence-based, theory-driven EX+DWL intervention, personalized to patient needs and delivered by our community partners, with those of the Arthritis Foundation's Walk With Ease (WWE) standard of care self-management program in the treatment of knee OA patients with overweight or obesity. The primary outcome of the CLIP-OA trial was mobility performance assessed using the 400-m walk test (400MWT). Secondary outcomes included weight loss, pain, select quality of life and social cognitive variables, and cost-effectiveness of intervention delivery. Findings from the CLIP-OA trial will determine the comparative and cost-effectiveness of the EX+DWL and WWE interventions on key clinical outcomes and has the potential to offer a sustainable medium for intervention delivery that can promote widely accessible weight management among knee OA patients with overweight or obesity. Trial Registration: NCT02835326.

Indexed as

Osteoarthritis, KneeAgedExercise TherapyHumansLife StyleObesityOverweightQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeWeight LossDietExerciseKnee osteoarthritisRandomized controlled trialWeight management

Identifiers

PMID35283261
PMCPMC9426348
OpenAlexW4220770846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.