ArticleThe Journal of allergy and clinical immunology2022
Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses.
Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Dietary, lifestyle, and environmental factors associated with ulcerative colitis: a systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2026Pooled it
- Chemical Components in the Breast Milk of Passive Smoker Women: A Systematic Review and Health Risks Assessment.Biological trace element research · 2025Pooled it
- Microbiome and pediatric leukemia, diabetes, and allergies: Systematic review and meta-analysis.PloS one · 2025Pooled it
- Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies.European journal of pediatrics · 2024Pooled it
- Exploratory integrative analysis of infant gut microbiome and metabolome suggests diet- and microbiome-derived metabolites associated with childhood asthma.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- MaternalBiomedicines · 2026Article
- Perinatal exposures and upper respiratory tract microbiome composition are associated with age at first acute otitis media episode.bioRxiv : the preprint server for biology · 2026Article
- Fast and reliable association discovery in large-scale microbiome studies and meta-analyses using PALM.bioRxiv : the preprint server for biology · 2026Article
- The respiratory microbiome influences the occurrence of respiratory diseases in children.Frontiers in pediatrics · 2026Review
- Gut microbiota as a therapeutic target of Chinese herbal medicine in allergic rhinitis: the gut-nasal axis and immunity.Frontiers in physiology · 2026Review
- Risk Factors and Predictors of Pneumonia Among Under-Five Children in Sana'a City, Yemen: A Multicenter Case-Control Study.Pediatric health, medicine and therapeutics · 2026Article
- Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review).Molecular medicine reports · 2026Review
- Distinct Nasal Microbiome Profiles and Prediction Model for Allergic Rhinitis, Nonallergic Rhinitis, and Healthy Children.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Associations between adverse childhood experiences and breastfeeding initiation and duration: a longitudinal birth cohort study in Pakistan.Research square · 2025Article
- Psychosocial Influences on Breastfeeding Duration: Maternal, Paternal, and Infant Contributors.Current developments in nutrition · 2025Review
- Early Origins of Asthma and Allergies: Clues From Studies in China.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Trajectories of gut microbiota and nonatopic wheeze: an early-life microbial footprint on preschool asthma.ERJ open research · 2025Article
- Observational birth cohorts for causal and predictive inference: The example of childhood asthma and allergic diseases.The Journal of allergy and clinical immunology · 2025Review
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13 authors at 3 institutions in 1 country.
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Abstract
backgroundThe impact of breast-feeding on certain childhood respiratory illnesses remains controversial.
objectiveWe sought to examine the effect of exclusive breast-feeding on the early-life upper respiratory tract (URT) and gut microbiome, the URT immune response in infancy, and the risk of common pediatric respiratory diseases.
methodsWe analyzed data from a birth cohort of healthy infants with prospective ascertainment of breast-feeding patterns and common pediatric pulmonary and atopic outcomes. In a subset of infants, we also characterized the URT and gut microbiome using 16S ribosomal RNA sequencing and measured 9 URT cytokines using magnetic bead-based assays.
resultsOf the 1949 infants enrolled, 1495 (76.71%) had 4-year data. In adjusted analyses, exclusive breast-feeding (1) had an inverse dose-response on the ⍺-diversity of the early-life URT and gut microbiome, (2) was positively associated with the URT levels of IFN-α, IFN-γ, and IL-17A in infancy, and (3) had a protective dose-response on the development of a lower respiratory tract infection in infancy, 4-year current asthma, and 4-year ever allergic rhinitis (odds ratio [95% CI] for each 4 weeks of exclusive breast-feeding, 0.95 [0.91-0.99], 0.95 [0.90-0.99], and 0.95 [0.92-0.99], respectively). In exploratory analyses, we also found that the protective association of exclusive breast-feeding on 4-year current asthma was mediated through its impact on the gut microbiome (P = .03).
conclusionsOur results support a protective causal role of exclusive breast-feeding in the risk of developing a lower respiratory tract infection in infancy and asthma and allergic rhinitis in childhood. They also shed light on potential mechanisms of these associations, including the effect of exclusive breast-feeding on the gut microbiome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.