ReviewHematology/oncology clinics of North America2022
Updates on the Diagnosis and Management of Cold Autoimmune Hemolytic Anemia.
Review in Hematology/oncology clinics of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Cast nephropathy in the ICU: Early recognition and extracorporeal strategies to improve outcomes.Journal of intensive medicine · 2026Review
- Childhood isolated C3d-positive AIHA: favorable prognosis but rare relapse or associated immunodeficiency.Blood advances · 2026Article
- Cryoproteins in Non-HCV-Related Autoimmune Disorders: A Serious Cold-Induced Problem.Diagnostics (Basel, Switzerland) · 2025Review
- A Case of Primary Cold Agglutinin-Mediated Hemolytic Anemia Successfully Treated with Steroids.Cureus · 2025Article
- Cold Agglutinin Disease in the Setting of Pancreatic Adenocarcinoma.European journal of case reports in internal medicine · 2025Article
- Investigating the Impact of Cold Agglutinins on Red Blood Cell Parameters in a Trauma Patient.Cureus · 2024Article
- Systemic Lupus Erythematosus Presenting With Cold-Antibody Autoimmune Hemolysis and Nephritis: A Case Report.Cureus · 2024Article
- Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.International journal of molecular sciences · 2024Review
- [Cold agglutinin syndrome associated with infectious mononucleosis: A case report].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Waldenström Macroglobulinemia - A State-of-the-Art Review: Part 1: Epidemiology, Pathogenesis, Clinicopathologic Characteristics, Differential Diagnosis, Risk Stratification, and Clinical Problems.Mediterranean journal of hematology and infectious diseases · 2024Review
- Hemolytic Anemia in the Setting of Atypical Pneumonia: A Case of Cold Agglutinin Disease.Cureus · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cold agglutinin disease represents a form of immune-mediated hemolytic anemia whereby an IgM protein either monoclonal or polyclonal deposits complement on the surface of the red blood cell. Once complement is deposited, the 3rd component of complement is recognized by receptors in the mononuclear phagocyte system resulting in spherocytic extravascular hemolysis. This results in a Coombs positive hemolytic anemia with the peripheral blood film showing agglutination. In many instances, the source is a clonal population of lymphoplasmacytic cells in the bone marrow producing a monoclonal IgM protein. Traditional and emerging therapies directed against the production of the IgM may have a positive effect on hemolytic anemia. Success in the management of cold agglutinin disease with rituximab, fludarabine, bortezomib, and bendamustine has all been reported. Recent studies have demonstrated that the blockade of complement with sutimlimab can stop the hemolysis without the use of systemic chemotherapy.
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