Evidence map›Paper›PMID 35282623›Full record

ArticleChemical science2022

Solvent directed chemically divergent synthesis of β-lactams and α-amino acid derivatives with chiral isothiourea.

Dong-Sheng Ji, Hui Liang, Kai-Xuan Yang, Zhi-Tao Feng, Yong-Chun Luo, Guo-Qiang Xu, Yucheng Gu, Peng-Fei Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dong-Sheng JiState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China xupf@lzu.edu.cn luoych@lzu.edu.cn.
Hui LiangState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China xupf@lzu.edu.cn luoych@lzu.edu.cn.
Kai-Xuan YangState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China xupf@lzu.edu.cn luoych@lzu.edu.cn.
Zhi-Tao FengDepartment of Chemistry, University of California Davis One Shields Avenue Davis California 95616 USA.
Yong-Chun LuoState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China xupf@lzu.edu.cn luoych@lzu.edu.cn.ORCID https://orcid.org/0000-0002-9567-7297
Guo-Qiang XuState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China xupf@lzu.edu.cn luoych@lzu.edu.cn.ORCID https://orcid.org/0000-0002-9683-4581
Yucheng GuSyngenta Jealott's Hill International Research Centre Bracknell Berkshire RG42 6EY UK.ORCID https://orcid.org/0000-0002-6400-6167
Peng-Fei XuState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China xupf@lzu.edu.cn luoych@lzu.edu.cn.ORCID https://orcid.org/0000-0002-5746-758X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A protocol for the chemically divergent synthesis of β-lactams and α-amino acid derivatives with isothiourea (ITU) catalysis by switching solvents was developed. The stereospecific Mannich reaction occurring between imine and C(1)-ammonium enolate generated zwitterionic intermediates, which underwent intramolecular lactamization and afforded β-lactam derivatives when DCM and CH

Identifiers

PMID35282623
PMCPMC8826511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.