ArticleFrontiers in endocrinology2022
A Randomized Cohort Study: Is It Worth the Time to Receive Antiandrogenic Pretreatment Before Ovulation Induction for Women With Polycystic Ovary Syndrome?
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association between preconception anti-androgen therapy and pregnancy outcomes of patients with PCOS: A prospective cohort study.Frontiers in endocrinology · 2023Article
- Role of luteinizing hormone elevation in outcomes of ovulation induction with letrozole for polycystic ovary syndrome.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Objective: To assess the effect of antiandrogenic pretreatment using combined oral contraceptives (COCs) before ovulation induction in infertile patients with polycystic ovary syndrome (PCOS) with hyperandrogenism. Design: Prospective, randomized open-labeled cohort study. Setting: Multicenter. Patients: PCOS patients with hyperandrogenism and requiring infertility treatments. Interventions: Randomization to direct ovulation induction of letrozole (letrozole group) or ethinylestradiol/cyproterone acetate (EE/CPA) for 3 months and subsequent letrozole-induced ovulation (EE/CPA+ letrozole group). The maximum number of ovulation induction cycle was three to four. Main Outcome Measures: Ovulation rate, conception rate, ongoing pregnancy rate, and live birth rate were the main outcomes of the study. Results: There were no significant differences in the cumulative ovulation, conception, ongoing pregnancy, and live birth rates between the letrozole and EE/CPA+ letrozole groups (cumulative ovulation: 206/254 [81.10%] Conclusions: The results of this study showed that COC pretreatment was not superior to direct letrozole-induced ovulation therapy in improving ovulation and pregnancy results in women with PCOS. There is no benefit to perform antiandrogenic therapy before ovulation induction in patients with PCOS in clinical practice. Clinical Trial Registration: www.clinicaltrials.gov, identifier ChiCTR1900022839.
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