Evidence map›Paper›PMID 35282421›Full record

ReviewMetabolism open2022

The effects of gender-affirming hormone therapy on cardiovascular and skeletal health: A literature review.

Nyein Chan Swe, Samihah Ahmed, Marwen Eid, Leonid Poretsky, Eugenia Gianos, Natalie E Cusano

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolism open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  5. Estrogen elicits ferroptosis-related myocardial oxidative stress and dysfunction in male rats.The Journal of pharmacology and experimental therapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nyein Chan SweDepartment of Cardiology, Cardiovascular Prevention, Lenox Hill Hospital, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.
Samihah AhmedDivision of Endocrinology, Lenox Hill Hospital, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Marwen EidDepartment of Cardiology, Cardiovascular Prevention, Lenox Hill Hospital, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.
Leonid PoretskyDepartment of Medicine, Lenox Hill Hospital, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Eugenia GianosZucker School and Medicine, 110 East 59th Street, Suite 8A, New York, NY, 10022, USA.
Natalie E CusanoZucker School of Medicine at Hofstra/Northwell, 110 East 59th Street, Suite 8B, New York, NY, 10022, USA.
Lenox Hill Hospital · USFeinstein Institute for Medical Research · USHofstra University · USNorthwell Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 1.5 million people in the United States currently identify as transgender. The use of gender affirming hormone therapy is integral to routine clinical care of transgender individuals, yet our understanding of the effects of this therapy is limited. There are reasons to believe that gender affirming hormone therapy may have important effects on cardiovascular risk and bone health in transgender individuals. The purpose of this review article is to summarize the evidence for the cardiovascular effects (including coronary artery disease, hypertension and stroke) as well as the effects on bone metabolism associated with gender affirming hormone therapy in both transgender men and transgender women.

Indexed as

Bone mineral densityCardiometabolicGender-affirming hormone therapyTrabecular bone scoreTransgender

Identifiers

PMID35282421
PMCPMC8907681
OpenAlexW4214927829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.