ArticleFrontiers in cardiovascular medicine2022
Establishment of a New Abdominal Aortic Aneurysm Model in Rats by a Retroperitoneal Approach.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 6 citations in OpenAlex.
- Exploring the potential mechanism of GABA in the treatment of abdominal aortic aneurysm through network pharmacology and experimental validation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats.Scientific reports · 2024Article
- A novel animal model of abdominal aortic aneurysm by mechanical injury.Experimental and therapeutic medicine · 2024Article
- A porcine model of thoracic aortic aneurysms created with a retrievable drug infusion stent graft mirrors human aneurysm pathophysiology.JVS-vascular science · 2024Article
- Article
- Progress in murine models of ruptured abdominal aortic aneurysm.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Background: Constructing an ideal model of abdominal aortic aneurysm (AAA) is of great significance to elucidate its complex pathogenesis. Therefore, we introduce a new and simple method to simulate human AAA and construct a rat AAA model through a retroperitoneal approach. Methods: Forty healthy adult Sprague Dawley (SD) rats were randomly divided into a control group, elastase + calcium chloride group (PPE+CaCl Results: The operation time of the four groups was controlled at approximately 40 min, and the success rate of the operation was 100%. Survival rate: Control Group (100%) = PPE Group (100%) > PPE + CaCl Conclusions: A new, simple, and reproducible rat AAA model can be constructed by a retroperitoneal approach. The pathological features of the three models are effective simulation of human AAA inflammatory cell infiltration, protease activity enhancement, and extracellular matrix destruction. The PPE+ CaCl
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