Evidence map›Paper›PMID 35282374›Full record

ArticleFrontiers in cardiovascular medicine2022

Combined Analysis of Myocardial Deformation and Oxygenation Detects Inducible Ischemia Unmasked by Breathing Maneuvers in Chronic Coronary Syndrome.

Barbara Spicher, Kady Fischer, Zoe A Zimmerli, Kyohei Yamaji, Yasushi Ueki, Carina N Bertschinger, Bernd Jung, Tatsuhiko Otsuka, Marius R Bigler, Christoph Gräni and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Barbara SpicherDepartment of Anaesthesiology and Pain Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Kady FischerDepartment of Anaesthesiology and Pain Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Zoe A ZimmerliDepartment of Anaesthesiology and Pain Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Kyohei YamajiDepartment of Cardiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Yasushi UekiDepartment of Cardiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Carina N BertschingerDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Bernd JungDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Tatsuhiko OtsukaDepartment of Cardiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Marius R BiglerDepartment of Cardiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Christoph GräniDepartment of Cardiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Hendrik von Tengg-KobligkDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Lorenz RäberDepartment of Cardiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Balthasar EberleDepartment of Anaesthesiology and Pain Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Dominik P GuenschDepartment of Anaesthesiology and Pain Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
University of Bern · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In patients with chronic coronary syndromes, hyperventilation followed by apnea has been shown to unmask myocardium susceptible to inducible deoxygenation. The aim of this study was to assess whether such a provoked response is co-localized with myocardial dysfunction. Methods: A group of twenty-six CAD patients with a defined stenosis (quantitative coronary angiography > 50%) underwent a cardiovascular magnetic resonance (CMR) exam prior to revascularization. Healthy volunteers older than 50 years served as controls ( Results: In healthy subjects, hyperventilation resulted in global myocardial deoxygenation (-10.2 ± 8.2%, Conclusion: In myocardium of patients with chronic coronary syndromes and primarily intermediate coronary stenoses, cine oxygenation-sensitive CMR can identify an impaired vascular and functional response to a vasoactive breathing maneuver stimulus indicative of inducible ischemia.

Indexed as

breathing maneuvercardiovascular magnetic resonancecoronary artery diseasefeature tracking (CMR-FT)oxygenation-sensitive imagingstrain

Identifiers

PMID35282374
PMCPMC8907543
OpenAlexW4213421156

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.