Evidence map›Paper›PMID 35282166›Full record

ArticleBrain communications2022

Sex-specific lesion pattern of functional outcomes after stroke.

Anna K Bonkhoff, Martin Bretzner, Sungmin Hong, Markus D Schirmer, Alexander Cohen, Robert W Regenhardt, Kathleen L Donahue, Marco J Nardin, Adrian V Dalca, Anne-Katrin Giese and 49 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

59 authors at 20 institutions in 13 countries.

Anna K BonkhoffJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Martin BretznerJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7594-4159
Sungmin HongJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Markus D SchirmerJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alexander CohenCenter for Brain Circuit Therapeutics, Department of Neurology, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-6557-5866
Robert W RegenhardtJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kathleen L DonahueJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marco J NardinJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Adrian V DalcaComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Boston, MA, USA.
Anne-Katrin GieseDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mark R EthertonJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4739-2449
Brandon L HancockAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Steven J T MockingAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Elissa C McIntoshAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
John AttiaHunter Medical Research Institute, Newcastle, NSW, Australia.
Oscar R BenaventeDepartment of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada.
Stephen BevanSchool of Life Sciences, University of Lincoln, Lincoln, UK.
John W ColeDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
Amanda DonattiSchool of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, SP, Brazil.
Christoph J GriessenauerDepartment of Neurosurgery, Geisinger, Danville, PA, USA.
Laura HeitschDepartment of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA.
Lukas HolmegaardDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Katarina JoodDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-8746-1771
Jordi Jimenez-CondeDepartment of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain.
Steven J KittnerDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
Robin LemmensDepartment of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-4948-5956
Christopher R LeviSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Caitrin W McDonoughDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL, USA.
James F MeschiaDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Chia-Ling PhuahDepartment of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital, St Louis, MO, USA.
Arndt RolfsCentogene AG, Rostock, Germany.
Stefan RopeleDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Jonathan RosandJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jaume RoquerDepartment of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain.
Tatjana RundekDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Ralph L SaccoDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Pankaj SharmaInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Agnieszka SlowikDepartment of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Martin SöderholmDepartment of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Alessandro SousaSchool of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, SP, Brazil.
Tara M StanneDepartment of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Daniel StrbianDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-9095-2344
Turgut TatlisumakDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Vincent ThijsStroke Division, Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia.
Achala VagalDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Johan WasseliusDepartment of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden.
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ramin ZandDepartment of Neurology, Geisinger, Danville, PA, USA.
Patrick F McArdleDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Bradford B WorrallDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
Christina JernDepartment of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Arne G LindgrenDepartment of Neurology, Skåne University Hospital, Lund, Sweden.
Jane MaguireUniversity of Technology Sydney, Sydney, Australia.
Michael D FoxCenter for Brain Circuit Therapeutics, Department of Neurology, Psychiatry, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Danilo BzdokDepartment of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University, Montreal, Canada.
Ona WuDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Natalia S RostJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium
Harvard University · USMassachusetts General Hospital · USSahlgrenska University Hospital · SELund University · SEUniversity of Maryland, Baltimore · USBarnes-Jewish Hospital · USBrigham and Women's Hospital · USGeisinger Medical Center · USMedical University of Graz · ATUniversidade Estadual de Campinas (UNICAMP) · BRUniversitat Autònoma de Barcelona · ESUniversity of Cincinnati Medical Center · USUniversity of Miami · USBoston Children's Hospital · USCentogene (Germany) · DEFlorey Institute of Neuroscience and Mental Health · AUHunter Medical Research Institute · AUJagiellonian University · PLJohn Hunter Hospital · AUMontreal Neurological Institute and Hospital · CA

Funding

DISCOVERY - Statistics and Analysis CoreU19NS115388 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg, Natalia S Rost · 2019 to 2026
$75.4M
Making Acute Stroke Trials Succeed: Challenges and Potential SolutionsU01NS110772 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Jordan J. Elm · 2020 to 2026
$24.3M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progressionR01AG068563 · NIA · MCGILL UNIVERSITY · PI BZDOK, DANILO, SPRENG, ROBERT NATHAN · 2020 to 2024
$2.3M
NIA NIH HHS R01 AG068563NINDS NIH HHS R01 NS114045NINDS NIH HHS U01 NS110772NINDS NIH HHS U19 NS115388
6 · The paper itself

Abstract

Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level.

Indexed as

acute ischaemic strokeBayesian hierarchical modellingfunctional outcomeslesion patternssex differences

Identifiers

PMID35282166
PMCPMC8914504
OpenAlexW4210496898

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.