Evidence map›Paper›PMID 35282153›Full record

ArticleMathematics (Basel, Switzerland)2021

A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment.

Rami Zakh, Alexander Churkin, William Bietsch, Menachem Lachiany, Scott J Cotler, Alexander Ploss, Harel Dahari, Danny Barash

Open access · goldAbstract read
In one paragraph

Article in Mathematics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Rami ZakhDepartment of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel.
Alexander ChurkinDepartment of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 8410501, Israel.
William BietschStritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Menachem LachianyJerusalem College of Technology, Jerusalem 91160, Israel.
Scott J CotlerStritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Alexander PlossDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Harel DahariStritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Danny BarashDepartment of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel.
Loyola University Chicago · USBen-Gurion University of the Negev · ILJerusalem College of Technology · ILPrinceton University · USSami Shamoon College of Engineering · IL

Funding

Data-Driven Mathematical and Computational Modeling of Hepatitis D Infection and Treatment ResponseR01AI146917 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL · 2020 to 2024
$3.5M
Mechanisms of hepatitis B virus cccDNA formationR01AI153236 · NIAID · PRINCETON UNIVERSITY · PI PLOSS, ALEXANDER · 2020 to 2024
$2.8M
Collaborative Integration of Hepatitis B Molecular Virology and Mathematical/Computational ModelingR01AI144112 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL, UPRICHARD, SUSAN L. · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144112NIAID NIH HHS R01 AI146917NIAID NIH HHS R01 AI153236
6 · The paper itself

Abstract

Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.

Indexed as

HDV-HBV coinfectionhepatitis delta virusviral kinetic models

Identifiers

PMID35282153
PMCPMC8916717
OpenAlexW4200016699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.