Evidence map›Paper›PMID 35282134›Full record

ArticleAnnals of translational medicine2022

Modification of STIM2 by m

Feng-Qiu Chen, Hao Zheng, Ting Gu, Yu-Hua Hu, Le Yang, Zhi-Ping Huang, Guang-Lei Qiao, Hong-Jie Li

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. METTL14‑mediated RNA methylation in digestive system tumors.International journal of molecular medicine · 2023
    Review
  5. Review
  6. Erratum to modification of STIM2 by mAnnals of translational medicine · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Feng-Qiu Chen *The Department of Biobank, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao Zheng *The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Ting Gu *Department of Oral Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu-Hua Hu *Department of Oral Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Le YangNational Liver Tissue Bank, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Zhi-Ping HuangDepartment of Hepatobiliary Surgery, General Hospital of Southern Theatre Command, Guangzhou, China.
Guang-Lei QiaoDepartment of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hong-Jie LiDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNSecond Military Medical University · CNShanghai Ninth People's Hospital · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: N6-methyladenosine (m Methods: The expression of STIM2 (Stromal Interaction Molecule 2) in CCA was measured using quantitative polymerase chain reaction (PCR) and immunohistochemistry (IHC). STIM2 was examined Results: Based on the GEPIA (Gene Expression Profiling Interactive Analysis) 2 database findings, a low STIM2 mRNA (messenger RNA) level was related to a poor prognosis in individuals with CCA. Quantitative PCR and IHC assays indicated decreased protein satin in CCA tissues and were associated with extrahepatic metastasis. Vianude mice tail vein injection model indicated that increased STIM2 levels suppressed CCA cell metastasis Conclusions: Our findings revealed the epi-transcriptomic dysregulation in CCA and metastasis by proposing a complicated STIM2-KRT8 regulatory paradigm based on m

Indexed as

Intrahepatic cholangiocarcinomaKRT8metastasisN6-methyladenosine (m6A)STIM2

Identifiers

PMID35282134
PMCPMC8848379
OpenAlexW4205718530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.