Evidence map›Paper›PMID 35282120›Full record

ArticleAnnals of translational medicine2022

Asiaticoside alleviates cardiomyocyte apoptosis and oxidative stress in myocardial ischemia/reperfusion injury via activating the

Xueliang Zeng, Junjian Yu, Peipei Liu, Yuan Liu, Taohui Zeng, Bei Li

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xueliang ZengDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Junjian YuCardiovascular and Thoracic Surgery Department 2, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Peipei LiuDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Yuan LiuDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Taohui ZengDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Bei LiDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
First Affiliated Hospital of Gannan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Myocardial ischemia/reperfusion (MI/R) is one of the most important links in myocardial injury, causing damage to cardiac tissues including cell apoptosis, oxidative stress, and other serious consequences. Asiaticoside (AS), a new compound synthesized from genistein, is cardioprotective. This paper presents new evidence for the protective role of AS against MI/R injury Methods: First, BALB/c mice underwent surgical ligation of the left anterior descending (LAD) artery to establish an MI/R animal model, and HL-1 cells were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) to establish an Results: In the Conclusions: The AS compound protects against MI/R injury by attenuating oxidative stress and apoptosis via activating the

Indexed as

apoptosisAsiaticoside (AS)ischemia/reperfusion injuryoxidative stressPI3K pathway

Identifiers

PMID35282120
PMCPMC8848378
OpenAlexW4205296248

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.