ArticleAnnals of translational medicine2022
Autophagy related long non-coding RNA and breast cancer prognosis analysis and prognostic risk model establishment.
Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Exposing the cellular situation: findings from single cell RNA sequencing in breast cancer.Frontiers in immunology · 2025Article
- OTUD6B-AS1: a multifaceted regulator of cancer with critical clinical implications.American journal of cancer research · 2025Review
- A circadian rhythm-related lncRNA signature correlates with prognosis and tumor immune microenvironment in head and neck squamous cell carcinoma.Discover oncology · 2024Article
- M2 Macrophage-Derived Exosomes Regulate miR-199a-3p Promoter Methylation Through the LINC00470-Mediated myc/DNMT3a Axis to Promote Breast Cancer Development.Biochemical genetics · 2024Article
- A novel arginine methylation-associated lncRNA signature effectively predicts prognosis in breast cancer patients.Frontiers in oncology · 2024Article
- Prediction of acute myeloid leukemia prognosis based on autophagy features and characterization of its immune microenvironment.Frontiers in immunology · 2024Article
- Insights from a Computational-Based Approach for Analyzing Autophagy Genes across Human Cancers.Genes · 2023Review
- Characteristics of mJournal of Cancer · 2023Article
- The current advances of lncRNAs in breast cancer immunobiology research.Frontiers in immunology · 2023Review
- Identification of a prognostic risk-scoring model and risk signatures based on glycosylation-associated cluster in breast cancer.Frontiers in genetics · 2022Article
- Prognosis Signature of Cuprotosis-Related lncRNAs Associated with Kidney Renal Clear Cell Carcinoma.Genetics research · 2022Article
- Risk Model and Immune Signature of m7G-Related lncRNA Based on Lung Adenocarcinoma.Frontiers in genetics · 2022Article
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4 authors.
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Abstract
Background: The role of autophagy-related long-stranded non-coding RNA (lncRNA) in breast cancer (BRCA) is unclear. We proposed to screen autophagy-related lncRNAs in BRCA and construct a prognostic risk assessment model to explore prognostic correlates. Methods: We extracted BRCA lncRNAs from The Cancer Genome Atlas (TCGA) database and autophagy-related genes from the Human Autophagy Database (HADb), to screen for autophagy-related lncRNA pairs (ARLP) in BRCA. Single-factor Cox regression analysis and multi-factor Cox regression analysis were used to screen lncRNAs associated with BRCA prognosis, and risk models were established. We divided BRCA patients into high-risk and low-risk groups based on median risk scores. The single-sample gene set enrichment analysis (ssGSEA) algorithm was used to calculate the abundance of 28 immune cells in the TCGA-BRCA cohort and to analyze the relationship between the risk score and the level of immune cell infiltration by ARLP characteristics. Results: Univariate Cox regression results showed that 42 ARLPs were significantly associated with overall survival (OS) in BRCA patients. Further multifactorial analysis showed that a total of 11 lncRNAs, including Conclusions: Our study suggested that a risk model consisting of 11 autophagy-related lncRNAs can be used to assess the prognosis of BRCA patients.
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