Evidence map›Paper›PMID 35281537›Full record

ArticleJournal of healthcare engineering2022

Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2.

Yongjie Qi, Yue Han, Chen Chen, Yingchang Xue, Nianhui Jiao, Xuejun Li

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. TiInternational journal of nanomedicine · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yongjie QiDepartment of Critical Care Medicine, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yue HanDepartment of Critical Care Medicine, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.
Chen ChenDepartment of Critical Care Medicine, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yingchang XueDepartment of Critical Care Medicine, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.
Nianhui JiaoDepartment of Critical Care Medicine, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.
Xuejun LiDepartment of Critical Care Medicine, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.ORCID 0000-0003-3319-6110
Jinan City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis can easily cause acute kidney injury (AKI) and seriously endanger human health. This article aims to investigate and study the role of microRNA-665 (miR-665) in septic AKI and the underlying molecular mechanism. Lipopolysaccharide (LPS) was used to construct cell and animal models of septic AKI. The expression of miR-665 in cells and kidney tissues was detected by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The contents of inflammatory factors (TNF-

Indexed as

Acute Kidney InjuryMicroRNAsAnimalsAntagomirsApoptosisFemaleHumansInterleukin-6LipopolysaccharidesMaleRatsTumor Necrosis Factor-alphaAntagomirsInterleukin-6LipopolysaccharidesMicroRNAsMIRN665 microRNA, humanMIRN665 microRNA, ratTumor Necrosis Factor-alpha

Identifiers

PMID35281537
PMCPMC8913057
OpenAlexW4214869239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.