Evidence map›Paper›PMID 35281490›Full record

ReviewFrontiers in neuroscience2022

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders.

Piyush Padhi, Carter Worth, Gary Zenitsky, Huajun Jin, Kumar Sambamurti, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Piyush PadhiParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Carter WorthParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Gary ZenitskyDepartment of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States.
Huajun JinDepartment of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States.
Kumar SambamurtiDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.
Vellareddy AnantharamDepartment of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States.
Arthi KanthasamyDepartment of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States.
Anumantha G KanthasamyParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.
University of Georgia · USIowa State University · USMedical University of South Carolina · US

Funding

Regional Brain Manganese Accumulation and Functional Consequences in WeldersR01ES019672 · NIEHS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2011 to 2021
$5.9M
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological RelevanceU01NS112008 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI, KANTHASAMY, ANUMANTHA GOUNDER · 2019 to 2023
$5.5M
Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity.R01ES026892 · NIEHS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2016 to 2020
$2.0M
Neuroinflammation and microglial Kv1.3 in Parkinsons diseaseR01NS100090 · NINDS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2017 to 2021
$1.9M
Synthetic biology for controlled releaseR01EB026533 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ELLINGTON, ANDREW D · 2019 to 2022
$1.4M
Novel Re-engineered L DOPA Probiotic Therapy for Parkinson's DiseaseR33NS112441 · NINDS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2022 to 2023
$765k
Dietary restriction and associated changes in gut microbiota to prevent Alzheimer diseaseR21AG062378 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAMBAMURTI, KUMAR · 2019 to 2020
$411k
Novel Re-engineered L DOPA probiotic therapy for Parkinsons DiseaseR61NS112441 · NINDS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2020 to 2020
$387k
NIA NIH HHS R21 AG062378NIBIB NIH HHS R01 EB026533NIEHS NIH HHS R01 ES019672NIEHS NIH HHS R01 ES026892NINDS NIH HHS R01 NS100090NINDS NIH HHS R33 NS112441NINDS NIH HHS R61 NS112441NINDS NIH HHS U01 NS112008
6 · The paper itself

Abstract

The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms. Beginning as early as

Indexed as

Alzheimer’s and Parkinson’s diseasesgut inflammationgut metabolomegut microbiotamicrobiomeneurodegenerationneuroinflammationprotein aggregation

Identifiers

PMID35281490
PMCPMC8914070
OpenAlexW4214648262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.