Evidence map›Paper›PMID 35281466›Full record

ArticleOxidative medicine and cellular longevity2022

5,8-Dihydroxy-4 ', 7-dimethoxyflavone Attenuates TNF-

Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Hsin-Hui Lin, Chuen-Mao Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chien-Chung YangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan 33302, Taiwan.ORCID https://orcid.org/0000-0003-2325-5017
Li-Der HsiaoDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Ya-Fang ShihDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Hsin-Hui LinDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Chuen-Mao YangDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0002-3208-5438
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we found that 5,8-dihydroxy-4',7-dimethoxyflavone (DDF) upregulated the expression of heme oxygenase (HO)-1 via p38 mitogen-activated protein kinase/nuclear factor-erythroid factor 2-related factor 2 (MAPK/Nrf2) pathway in human cardiac fibroblasts (HCFs). However, the alternative processes by which DDF induces the upregulation of HO-1 expression are unknown. Activation of epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and protein kinase C (PKC)

Indexed as

ErbB ReceptorsFibroblastsHeme Oxygenase-1HumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Small InterferingTransfectionTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1ErbB ReceptorsHeme Oxygenase-1Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Small InterferingTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID35281466
PMCPMC8916851
OpenAlexW4221002267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.