Evidence map›Paper›PMID 35281444›Full record

ArticleFrontiers in cellular and infection microbiology2022

Gut Microbiota Associated With Effectiveness And Responsiveness to Mindfulness-Based Cognitive Therapy in Improving Trait Anxiety.

Zonghua Wang, Shuang Liu, Xiaoxiao Xu, Yufeng Xiao, Min Yang, Xiaoyan Zhao, Cancan Jin, Feng Hu, Shiming Yang, Bo Tang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  8. Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  9. Severity of Depressive Symptoms by Perceived Stress and Gut Microbiota Composition: A Sex-Stratified Bayesian Approach in a Non-Clinical Sample.Stress and health : journal of the International Society for the Investigation of Stress · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Zonghua WangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Shuang LiuDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xiaoxiao XuDepartment of Basic Psychology, School of Psychology, Army Medical University, Chongqing, China.
Yufeng XiaoDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Min YangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Xiaoyan ZhaoDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Cancan JinDepartment of Basic Psychology, School of Psychology, Army Medical University, Chongqing, China.
Feng HuDepartment of Basic Psychology, School of Psychology, Army Medical University, Chongqing, China.
Shiming YangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Bo TangDepartment of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Caiping SongDepartment of Nursing, Xinqiao Hospital, Army Medical University, Chongqing, China.
Tao WangDepartment of Basic Psychology, School of Psychology, Army Medical University, Chongqing, China.
Army Medical University · CNXinqiao Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Mindfulness-based interventions have been widely demonstrated to be effective in reducing stress, alleviating mood disorders, and improving quality of life; however, the underlying mechanisms remained to be fully understood. Along with the advanced research in the microbiota-gut-brain axis, this study aimed to explore the impact of gut microbiota on the effectiveness and responsiveness to mindfulness-based cognitive therapy (MBCT) among high trait anxiety populations. Design: A standard MBCT was performed among 21 young adults with high trait anxiety. A total of 29 healthy controls were matched for age and sex. The differences in gut microbiota between the two groups were compared. The changes in fecal microbiota and psychological indicators were also investigated before and after the intervention. Results: Compared with healthy controls, we found markedly decreased bacterial diversity and distinctive clusters among high trait anxiety populations, with significant overgrowth of bacteria such as Conclusion: The significantly increased diversity post-MBCT added evidence to gut-brain communication and highlighted the utility of mycobiota-focused strategies for promoting the effectiveness and responsiveness of the MBCT to improve trait anxiety. Clinical Trial Registration: chictr.org.cn, ChiCTR1900028389.

Indexed as

Cognitive Behavioral TherapyGastrointestinal MicrobiomeMindfulnessAnxietyDepressionHumansQuality of LifeTreatment OutcomeYoung Adulteffectivenessgut microbiomemindfulness-based cognitive therapyresponsivenesstrait anxiety

Identifiers

PMID35281444
PMCPMC8908961
OpenAlexW4225995530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.