Trial reportDrug design, development and therapy2022
Determination of the Dose-Response Relationship of Epidural Dexmedetomidine Combined with Ropivacaine for Labor Analgesia.
Trial report in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07007650 (Effects of Different Concentrations of Ropivacaine on Prolonged Labor Analgesia), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Different Concentrations of Ropivacaine on Prolonged Labor Analgesia
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Determination of Median Effective Concentration (ECDrug design, development and therapy · 2026Trial
- Determining the Optimal Volume of Ropivacaine Combined with Dexmedetomidine for Programmed Intermittent Epidural Bolus in Labor Analgesia: A Randomized Dose-Response Study.Drug design, development and therapy · 2026Trial
- Optimal Interval for Intermittent Epidural Bolus with Ropivacaine-Dexmedetomidine Using the Epidural Dural Puncture Technique for Labour Analgesia: A Coin Bias Up-Down Study.Drug design, development and therapy · 2026Trial
- Trial
- Analgesic efficacy, adverse events, and prognostic factors of low-dose intranasal dexmedetomidine combined with epidural anesthesia in ovarian cyst resection.American journal of translational research · 2025Article
- Article
- EDFrontiers in pharmacology · 2023Article
- Determination of the 95% effective dose of remimazolam tosylate in anesthesia induction inhibits endotracheal intubation response in senile patients.Frontiers in pharmacology · 2023Article
- The Median Effective Dose of Dexmedetomidine for the Inhibition of Emergence Delirium in Preschool Children Undergoing Tonsillectomy and/or Adenoidectomy: A Retrospective Dose-response Trial.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The safety and efficacy of dexmedetomidine for epidural labor analgesia have been reported in numerous literatures, but the optimal dose has not been fully determined. The objective of this study was to determine the dose-response relationship of epidural dexmedetomidine (combined with ropivacaine) for labor analgesia. Methods: A total of 120 full-term laboring parturients requesting epidural labor analgesia were enrolled in the study from July 5, 2020 to September 22, 2021. The parturients were randomly assigned to receive 0, 0.1, 0.2, 0.3, 0.4 or 0.5 μg/mL dexmedetomidine combined with 0.075% ropivacaine epidurally. An effective dose was defined as numerical rating scale (NRS) pain score ≤3 at 30-minutes of epidural drug injection. The dose-response relationship of dexmedetomidine (with ropivacaine) for epidural labor analgesia was performed using probit regression. The median effective dose (ED Results: The estimated values of ED Conclusion: The ED
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.