Evidence map›Paper›PMID 35281275›Full record

ArticleFrontiers in molecular biosciences2022

Impact of a Single Nucleotide Polymorphism on the 3D Protein Structure and Ubiquitination Activity of E3 Ubiquitin Ligase Arkadia.

Maria Birkou, Vasilios Raptis, Konstantinos D Marousis, Athanasios Tsevis, Kyriakos Bourikas, Detlef Bentrop, Vasso Episkopou, Georgios A Spyroulias

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Maria BirkouDepartment of Pharmacy, University of Patras, Patras, Greece.
Vasilios RaptisDepartment of Pharmacy, University of Patras, Patras, Greece.
Konstantinos D MarousisDepartment of Pharmacy, University of Patras, Patras, Greece.
Athanasios TsevisSchool of Science and Technology, Hellenic Open University, Patras, Greece.
Kyriakos BourikasSchool of Science and Technology, Hellenic Open University, Patras, Greece.
Detlef BentropInstitute of Physiology II, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Vasso EpiskopouFaculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes, London, United Kingdom.
Georgios A SpyrouliasDepartment of Pharmacy, University of Patras, Patras, Greece.
University of Patras · GRHellenic Open University · GRHammersmith Hospital · GBUniversity of Freiburg · DE

Funding

Medical Research Council MR/J013331/1Medical Research Council MR/M011194/1
6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNPs) are genetic variations which can play a vital role in the study of human health. SNP studies are often used to identify point mutations that are associated with diseases. Arkadia (RNF111) is an E3 ubiquitin ligase that enhances transforming growth factor-beta (TGF-

Indexed as

ArkadiaE3 ligaseNMRRINGsnps

Identifiers

PMID35281275
PMCPMC8905620
OpenAlexW4213032404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.