Evidence map›Paper›PMID 35281262›Full record

ArticleFrontiers in molecular biosciences2022

Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice.

Jinxin Gu, Lixue Chen, Ran Sun, Jie-Li Wang, Juntao Wang, Yingjun Lin, Shuwen Lei, Yang Zhang, Dan Lv, Faqin Jiang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jinxin GuSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Lixue ChenSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Ran SunSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Jie-Li WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Juntao WangSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Yingjun LinSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Shuwen LeiSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Yang ZhangSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Dan LvSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Faqin JiangSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Yuru DengWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
James P CollmanDepartment of Chemistry, Stanford University, Stanford, CA, United States.
Lei FuSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Jiao Tong University · CNUniversity of Chinese Academy of Sciences · CNStanford University · USXi’an Jiaotong-Liverpool University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegeneration is a pathological condition in which nervous system or neuron losses its structure, function, or both leading to progressive neural degeneration. Growing evidence strongly suggests that reduction of plasmalogens (Pls), one of the key brain lipids, might be associated with multiple neurodegenerative diseases, including Alzheimer's disease (AD). Plasmalogens are abundant members of ether-phospholipids. Approximately 1 in 5 phospholipids are plasmalogens in human tissue where they are particularly enriched in brain, heart and immune cells. In this study, we employed a scheme of 2-months Pls intragastric administration to aged female C57BL/6J mice, starting at the age of 16 months old. Noticeably, the aged Pls-fed mice exhibited a better cognitive performance, thicker and glossier body hair in appearance than that of aged control mice. The transmission electron microscopic (TEM) data showed that 2-months Pls supplementations surprisingly alleviate age-associated hippocampal synaptic loss and also promote synaptogenesis and synaptic vesicles formation in aged murine brain. Further RNA-sequencing, immunoblotting and immunofluorescence analyses confirmed that plasmalogens remarkably enhanced both the synaptic plasticity and neurogenesis in aged murine hippocampus. In addition, we have demonstrated that Pls treatment inhibited the age-related microglia activation and attenuated the neuroinflammation in the murine brain. These findings suggest for the first time that Pls administration might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.

Indexed as

agingmicroglianeurogenesisneuroinflammationplasmalogensynaptogenesis

Identifiers

PMID35281262
PMCPMC8906368
OpenAlexW4212776507

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.