ArticleFrontiers in pediatrics2022
Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review.
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of Antibiotics and Anti-Inflammatory Drugs on Enamel Development: A Systematic Review with Quantitative Synthesis.International dental journal · 2026Pooled it
- Influence of Vitamin D on Developmental Defects of Enamel (DDE) in Children and Adolescents: A Systematic Review.Nutrients · 2025Pooled it
- Are low serum levels of Vitamin D associated with dental developmental defects in primary teeth? A systematic review.Evidence-based dentistry · 2024Pooled it
- Presumptive Bilirubin-Related Chlorodontia and Developmental Enamel Defects of the Primary Dentition in an Extremely Preterm Infant: A Case Report.Journal of clinical medicine · 2026Article
- Article
- Validating Dental Histology for Perinatal Age Estimation Using Human Deciduous Teeth.American journal of biological anthropology · 2026Article
- Expert consensus on the diagnosis and management of tooth developmental anomalies.International journal of oral science · 2026Review
- The Interplay of Immune Response and Dental Enamel Formation in Health and Sickness.Advances in experimental medicine and biology · 2026Review
- Investigation of the most common perinatal and postnatal risk factors in children with MIH compared to healthy (non-MIH) children aged 6-12 years in Arak City.BMC oral health · 2025Article
- Developmental Defect of Enamel in Permanent Teeth Associated With Chronic Endodontic Abscess in Deciduous Teeth: A Retrospective Study.Clinical and experimental dental research · 2025Article
- State of knowledge of the relationship between celiac disease and oral pathology: A scoping review.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Substance use during pregnancy and childhood dental caries: a Brazilian cohort study.Scientific reports · 2025Article
- Long-Term Oro-Dental Effects of Chemotherapy in a Pediatric Patient: A Case Study and a Proposed Oral Care Protocol.Journal of clinical medicine · 2025Article
- Associations between enamel defects and caries in patients with Down syndrome compared with normotypic patients.Brazilian oral research · 2025Article
- The intricacies of tooth enamel: Embryonic origin, development and human genetics.Journal of structural biology · 2024Review
- Is Italian Dentists' Knowledge of Enamel Development Defects Adequate? A Nationwide Survey.International dental journal · 2024Article
- Molar Incisor Hypomineralization: Etiology, Correlation with Tooth Number Anomalies and Implications for Comprehensive Management Strategies in Children from Transylvania.Diagnostics (Basel, Switzerland) · 2024Article
- Differences in childhood stress between Neanderthals and early modern humans as reflected by dental enamel growth disruptions.Scientific reports · 2024Article
- Establishment of a clinical network for children with amelogenesis imperfecta and dentinogenesis imperfecta in the UK: 4-year experience.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Association of defects of enamel with polymorphisms in the vitamin D receptor and parathyroid hormone genes.Brazilian dental journal · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Developmental Defects of Enamel (DDE) is a pathology of the teeth that can greatly alter the quality of life of patients (hypersensitivity, esthetic issues, loss of function, etc.). The acquired DDE may occur as a result of a wide range of acquired etiological factors and his prevalence of this pathology may reach up to 89.9%. The main objective of this research was to identify and analyze, in current literature, the factors related to acquired DDE, in order to propose a general theory about the mechanisms involved. Methods: The search of the primary literature was conducted until [December 31, 2021]. Our search strategy uses the Pubmed/MEDLINE database and was structured around 3 terms ["Development," "Defect," and "Enamel"]. To be included, references had to be primary studies, written in English. Exclusion criteria were reviews, Results: A scoping review of the literature identified 114 factors potentially involved in acquired DDE. The most frequently encountered pathologies are those causing a disorder of calcium homeostasis or a perturbation of the ARNT pathway in mother or child. The link between the ARNT pathway and metabolism deficiency in uncertain and needs to be defined. Also, the implication of this mechanism in tissue impairment is still unclear and needs to be explored. Conclusions: By identifying and grouping the risk factors cited in the literature, this taxonomy and the hypotheses related to the mechanism allow health practitioners to adopt behaviors that limit the risk of developing aDDE and to set up a prevention of dental pathology. In addition, by reviewing the current literature, this work provides guidance for basic research, clinical studies, and literature searches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.