Evidence map›Paper›PMID 35281095›Full record

ReviewFrontiers in cell and developmental biology2022

Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles.

Pin-Chao Liao, Emily J Yang, Taylor Borgman, Istvan R Boldogh, Cierra N Sing, Theresa C Swayne, Liza A Pon

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Ion- and Temperature-Programmable Reconfiguration of Subcompartments in Synthetic Cells.Chembiochem : a European journal of chemical biology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Cofilin(s) and Mitochondria: Function Beyond Actin Dynamics.International journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. HIV infection drives proinflammatory adipocyte differentiation in anFrontiers in cellular and infection microbiology · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Unexpected omega-3 activities in intracellular lipolysis and macrophage foaming revealed by fluorescence lifetime imaging.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Pin-Chao LiaoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Emily J YangDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Taylor BorgmanInstitute of Human Nutrition, Columbia University Irving Medical Center, New York, NY, United States.
Istvan R BoldoghDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Cierra N SingInstitute of Human Nutrition, Columbia University Irving Medical Center, New York, NY, United States.
Theresa C SwayneHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, United States.
Liza A PonDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Columbia University Irving Medical Center · USNational Tsing Hua University · TW

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
NCI NIH HHS P30 CA013696
6 · The paper itself

Abstract

Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at membrane contact sites (MCS) between LDs and other organelles. MCS are sites of transfer of cellular constituents to or from LDs for energy mobilization in response to nutrient limitations, as well as LD biogenesis, expansion and autophagy. Here, we describe recent findings on the mechanisms underlying the formation and function of MCS between LDs and mitochondria, ER and lysosomes/vacuoles and the role of the cytoskeleton in promoting LD MCS through its function in LD movement and distribution in response to environmental cues.

Indexed as

cytoskeletonendoplasmic reticulumlipid dropletslipophagylysosomemembrane contact sitesmitochondriavacuole

Identifiers

PMID35281095
PMCPMC8908909
OpenAlexW4213445367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.