Evidence map›Paper›PMID 35281038›Full record

ReviewFrontiers in immunology2022

HLA-G and the MHC Cusp Theory.

Bruna Miglioranza Scavuzzi, Vincent van Drongelen, Joseph Holoshitz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bruna Miglioranza ScavuzziDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
Vincent van DrongelenDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
Joseph HoloshitzDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

TRAINING OF ARTHRITIS RESEARCH SCIENTISTST32AR007080 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 1986 to 2026
$6.3M
Immune Modulating HLA-Coded Ligands in Rheumatoid ArthritisR01AR059085 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2011 to 2020
$3.8M
Gene-environment interaction pathways in rheumatoid arthritisR01AR074930 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2019 to 2023
$2.6M
Class II MHC Allele-Specific Signaling: A New Paradigm in Disease PathogenesisR01GM088560 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2009 to 2012
$1.2M
Cellular Activation Pathways in Rheumatoid ArthritisR01AR046468 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2001 to 2004
$1.0M
Empirical validation of a novel HLA-disease association theory in skin and rheumatic diseasesR61AR073014 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2017 to 2018
$770k
Empirical validation of a novel HLA-disease association theory in skin and rheumatic diseasesR33AR073014 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2019 to 2019
$390k
MHC class II-Associated Endothelial DysfunctionR21AR056786 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2009 to 2010
$379k
Immune dysregulation by the rheumatoid arthritis shared epitopeR21AR055170 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2008 to 2009
$367k
NIAMS NIH HHS R01 AR046468NIAMS NIH HHS R01 AR059085NIAMS NIH HHS R01 AR074930NIAMS NIH HHS R21 AR055170NIAMS NIH HHS R21 AR056786NIAMS NIH HHS R33 AR073014NIAMS NIH HHS R61 AR073014NIAMS NIH HHS T32 AR007080NIGMS NIH HHS R01 GM088560
6 · The paper itself

Abstract

Human leukocyte antigens (HLA) are significant genetic risk factors in a long list of diseases. However, the mechanisms underlying these associations remain elusive in many cases. The best-characterized function of classical major histocompatibility complex (MHC) antigens is to allow safe presentation of antigenic peptides

Indexed as

Autoimmune DiseasesHLA-G AntigensAllelesHumansLigandsMajor Histocompatibility ComplexHLA-G AntigensLigandsantigen presentation (AP)Cusp theoryHLA-disease associationHLA-Ghuman leukocyte antigen (HLA)immunity

Identifiers

PMID35281038
PMCPMC8913506
OpenAlexW4214725173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.