Evidence map›Paper›PMID 35281029›Full record

ArticleFrontiers in immunology2022

Simian Immunodeficiency Virus Infection Mediated Changes in Jejunum and Peripheral SARS-CoV-2 Receptor ACE2 and Associated Proteins or Genes in Rhesus Macaques.

Nongthombam Boby, Xuewei Cao, Kelsey Williams, Shiva Kumar Goud Gadila, Monica N Shroyer, Peter J Didier, Sudesh K Srivastav, Arpita Das, Kate Baker, Qiuying Sha and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Nongthombam BobyDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States.
Xuewei CaoDepartment of Mathematical Sciences, Michigan Technological University, Houghton, MI, United States.
Kelsey WilliamsDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States.
Shiva Kumar Goud GadilaDivision of Immunology, Tulane National Primate Research Center, Covington, LA, United States.
Monica N ShroyerDivision of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, United States.
Peter J DidierDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States.
Sudesh K SrivastavDepartment of Biostatistics, Tulane University, New Orleans, LA, United States.
Arpita DasDivision of Microbiology, Tulane National Primate Research Center, Covington, LA, United States.
Kate BakerDivision of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, United States.
Qiuying ShaDepartment of Mathematical Sciences, Michigan Technological University, Houghton, MI, United States.
Bapi PaharDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States.
Tulane University · USMichigan Technological University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONSP51RR000164 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI ROY, CHAD J. · 1985 to 2011
$100.1M
Impact of HIV/SIV Infection on Paneth and Intestinal Stem Cell InteractionR01DK109883 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI DIDIER, PETER J · 2017 to 2020
$3.0M
NIDDK NIH HHS R01 DK109883
6 · The paper itself

Abstract

Angiotensin converting enzyme-2 (ACE2) and associated proteins play a pivotal role in various physiological and pathological events, such as immune activation, inflammation, gut barrier maintenance, intestinal stem cell proliferation, and apoptosis. Although many of these clinical events are quite significant in SIV/HIV infection, expression profiling of these proteins has not been well reported. Considering the different pathological consequences in the gut after HIV infection, we hypothesized that the expression of ACE2 and associated proteins of the Renin-angiotensin system (RAS) could be compromised after SIV/HIV infection. We quantified the gene expression of

Indexed as

Angiotensin-Converting Enzyme 2AnimalsCD4-Positive T-LymphocytesCells, CulturedCytokinesDipeptidyl Peptidase 4Gene Expression RegulationHumansInflammation MediatorsJejunumMacaca mulattaReceptor, Angiotensin, Type 2Simian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAGTR2 protein, humanAngiotensin-Converting Enzyme 2CytokinesDipeptidyl Peptidase 4DPP4 protein, humanInflammation MediatorsReceptor, Angiotensin, Type 2ACE2 regulationAGTR2enteroids/organoidsMIP-1mucosal immunityrhesus macaqueSIV/HIVtranscriptomics

Identifiers

PMID35281029
PMCPMC8914048
OpenAlexW4214676164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.