Evidence map›Paper›PMID 35281011›Full record

ArticleFrontiers in immunology2022

Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination.

Ayman Al Jurdi, Rodrigo B Gassen, Thiago J Borges, Zhabiz Solhjou, Frank E Hullekes, Isadora T Lape, Orhan Efe, Areej Alghamdi, Poojan Patel, John Y Choi and 8 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Tixagevimab/cilgavimab pre-exposure prophylaxis is associated with lower breakthrough infection risk in vaccinated solid organ transplant recipients during the omicron wave.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Ayman Al JurdiCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Rodrigo B GassenCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Thiago J BorgesCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Zhabiz SolhjouTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, United States.
Frank E HullekesCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Isadora T LapeCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Orhan EfeCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Areej AlghamdiTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, United States.
Poojan PatelTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, United States.
John Y ChoiTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, United States.
Mostafa T MohammedTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, United States.
Brigid BohanHistocompatibility Laboratory, Massachusetts General Hospital, Boston, MA, United States.
Vikram PattanayakDepartment of Pathology, Massachusetts General Hospital, Boston, MA, United States.
Ivy RosalesDepartment of Pathology, Massachusetts General Hospital, Boston, MA, United States.
Paolo CravediRenal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Camille N KottonTransplant and Immunocompromised Host Infectious Diseases Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jamil R AzziTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, United States.
Leonardo V RiellaCenter for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.
Massachusetts General Hospital · USBrigham and Women's Hospital · USHarvard University · USIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Studies have shown reduced antiviral responses in kidney transplant recipients (KTRs) following SARS-CoV-2 mRNA vaccination, but data on post-vaccination alloimmune responses and antiviral responses against the Delta (B.1.617.2) variant are limited. Materials and methods: To address this issue, we conducted a prospective, multi-center study of 58 adult KTRs receiving mRNA-BNT162b2 or mRNA-1273 vaccines. We used multiple complementary non-invasive biomarkers for rejection monitoring including serum creatinine, proteinuria, donor-derived cell-free DNA, peripheral blood gene expression profile (PBGEP), urinary Results: At a median of 85 days, no KTRs developed Conclusions: SARS-CoV-2 mRNA vaccination in KTRs did not elicit a significant alloimmune response. About half of KTRs who develop anti-wild-type spike antibodies after two mRNA vaccine doses have neutralizing responses against the Delta variant. There was no association between anti-viral humoral and cellular responses.

Indexed as

Kidney Transplantation2019-nCoV Vaccine mRNA-1273AgedAntibodies, ViralBNT162 VaccineEnzyme-Linked Immunospot AssayFemaleGraft RejectionHumansImmunity, CellularIsoantibodiesMaleMiddle AgedMonitoring, PhysiologicProspective StudiesSARS-CoV-22019-nCoV Vaccine mRNA-1273Antibodies, ViralBNT162 VaccineIsoantibodiesCOVID-19kidney transplantmonitoringrejectionSARS-CoV-2vaccine

Identifiers

PMID35281011
PMCPMC8913529
OpenAlexW4214601934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.