Evidence map›Paper›PMID 35281000›Full record

ArticleFrontiers in immunology2022

Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 Patients.

Xiaorui Wang, Han Bai, Junpeng Ma, Hongyu Qin, Qiqi Zeng, Fang Hu, Tingting Jiang, Weikang Mao, Yang Zhao, Xiaobei Chen and 17 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 4 institutions in 2 countries.

Xiaorui WangPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Han BaiPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Junpeng MaPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Hongyu QinPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Qiqi ZengPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Fang HuPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Tingting JiangLC-Bio Technologies, Co., Ltd., Hangzhou, China.
Weikang MaoLC-Bio Technologies, Co., Ltd., Hangzhou, China.
Yang ZhaoDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Xiaobei ChenDepartment of Infectious Diseases, The Renmin Hospital of Wuhan University, Wuhan, China.
Xin QiPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Mengyang LiPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jiao XuPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jingcan HaoCancer Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yankui WangDialysis Center, The Renmin Hospital of Wuhan University, Wuhan, China.
Xi DingDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yuanrui LiuLC-Bio Technologies, Co., Ltd., Hangzhou, China.
Tianlong HuangLC-Bio Technologies, Co., Ltd., Hangzhou, China.
Chao FangLC-Bio Technologies, Co., Ltd., Hangzhou, China.
Changli GeLC-Bio Technologies, Co., Ltd., Hangzhou, China.
Dong LiDepartment of Clinical Laboratory, The Renmin Hospital of Wuhan University, Wuhan, China.
Ke HuDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Xianwen RenBiomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Baojun ZhangDepartment of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Binghong ZhangThe Renmin Hospital of Wuhan University, Wuhan, China.
Bingyin ShiDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chengsheng ZhangPrecision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNWuhan University · CNJackson Laboratory · USPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 using scRNA-seq technology coupled with a deep and comprehensive analysis of unique cell surface markers and differentially expressed genes. We revealed that (TRAV1-2

Indexed as

Asymptomatic InfectionsCOVID-19FemaleFlow CytometryHumansImmunophenotypingKiller Cells, NaturalMaleMiddle AgedMonocytesMucosal-Associated Invariant T CellsNatural Killer T-CellsSARS-CoV-2Severity of Illness IndexViral Loadasymptomatic infectionCOVID-19disease severitySARS-CoV-2singlecell RNA sequencing (scRNA-seq)viral persistence

Identifiers

PMID35281000
PMCPMC8905648
OpenAlexW4212778527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.