Evidence map›Paper›PMID 35280869›Full record

ArticleFrontiers in medicine2022

Associations Between Keratoconus and the Level of Sex Hormones: A Cross-Sectional Study.

Xiaorui Zhao, Yifei Yuan, Tong Sun, Yu Zhang, Yueguo Chen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Trends in the Management of Keratoconus in Australia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  4. Review
  5. Article
  6. Sex Hormones and Keratoconus: In Search of the Link.Journal of clinical medicine · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Five novelZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  13. The Impact of Sex Hormones on Keratoconus.Journal of clinical medicine · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Gender-specific association ofFrontiers in genetics · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaorui ZhaoDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yifei YuanDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Tong SunDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yu ZhangDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yueguo ChenDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Peking University · CNPeking University Third Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To analyze the level of sex hormone in relation to keratoconus (KC). Methods: Sixty-two eyes of 62 patients (12 females, 50 males) classified as KC and 120 eyes of 120 patients (21 females, 99 males) with mild to moderate myopia and astigmatism were analyzed. Plasma samples were collected and analyzed using a chemiluminescence immunoassay to determine the concentrations of estriol (E Results: The mean age was 23.73 ± 5.16 years for patients with KC and 23.68 ± 6.10 years for patients treated with laser vision correction (LVC). Among the patients with KC, 12 were female (19.35%) and 50 were male (80.65%). The majority of patients with KC were between 20 and 30 years old. In female patients, the concentration of T in the KC group was significantly lower than that in the LVC group (0.86 ± 0.33 vs. 1.18 ± 0.58 nmol/L; Conclusions: Conclusively, our results showed that T level was reduced in both female and male KC plasma, while E

Indexed as

etiopathogenesiskeratoconusmatrix metalloproteinasesproinflammatory cytokinesex hormone

Identifiers

PMID35280869
PMCPMC8908379
OpenAlexW4213425078

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.