ReviewFrontiers in medicine2022
Challenges in Multimorbidity Research: Lessons Learned From the Most Recent Randomized Controlled Trials in Primary Care.
Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Co-designing care for multimorbidity: a systematic review.BMC medicine · 2024Pooled it
- Model of integrated mental health video consultations for people with depression or anxiety in primary care (PROVIDE-C): assessor masked, multicentre, randomised controlled trial.BMJ (Clinical research ed.) · 2024Trial
- Symptom burden in multiple long-term conditions: An AI-supported, mixed-methods concept elicitation study.JRSM open · 2026Article
- Primary care and community interventions for multimorbidity involving depression or anxiety: systematic review with meta-analysis.BMJ medicine · 2026Article
- Article
- Rising to the challenges of research in multiple long-term conditions: health and social care research ecosystem approaches.BMJ open · 2025Review
- Article
- Multimorbidity clusters: translating research evidence into actionable interventions.European geriatric medicine · 2025Article
- The Multimorbidity Questionnaire (MMQ1): English translation and validation of a Danish patient reported outcome measure for quality of life in people with multiple long-term conditions in a cross-sectional survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Article
- The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries.BMC geriatrics · 2024Article
- Perspectives on common chronic diseases in adult cancer patients in South Africa.Global health action · 2023Article
- Variations in quality of life in people with multimorbidity: A cross-sectional survey comparing MMQ1 and EQ-5D-5L.Journal of multimorbidity and comorbidityArticle
- Improving person-centered care for people with multimorbidity: the potential of participatory learning and action research.Journal of multimorbidity and comorbidityArticle
- Implementation of the virtual transitional care stroke intervention for older adults with stroke and multimorbidity: A qualitative descriptive study.Journal of multimorbidity and comorbidityArticle
- Primary Care Research: Looking Back and Moving Forward With Reflections on NAPCRG's First 50 Years.Annals of family medicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multimorbidity has received much attention and there is a growing number of original studies. However, randomized controlled trials (RCTs) have failed to demonstrate effectiveness of interventions aimed at improving outcomes for patient with multimorbidity in primary care. The purpose of this article is to synthesize and analyze the most recent RCTs to identify the factors that may have contribute to the success or lack of success in order to draw lessons to inform further development in intervention research. A scoping review was conducted to include current up-to-date state-of-the-art studies in primary care published from 2019. Nine articles reporting on six RCTs studies were included in the review. The findings were mixed, with primary outcomes showing no differences between intervention and control groups in four of the six but differences in secondary outcomes in all six. All studies involved family practice patients but interventions took place at different sites, and the time between the beginning of the intervention and the time of evaluation of outcomes varied across studies. Authors reported issues regarding the need for training of care teams, the roles and composition of the teams, the selection of patients and implementation barriers of the complex interventions in trying contexts with not enough time for the changes required. The randomized controlled design may not be the best evaluation design given the complexity of the interventions, and alternative designs should be considered in which qualitative components are included. Further attention to outcome measures and to equity issues is recommended.
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What OpenQuestion holds
Registered trials
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