ArticleFrontiers in oncology2022
Comparison of the Characteristics and Prognosis Between Very Young Women and Older Women With Breast Cancer: A Multi-Institutional Report From China.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.Breast cancer research : BCR · 2023Pooled it
- Mothers' experiences of having a daughter with breast cancer in Chinese families: A qualitative study.Asia-Pacific journal of oncology nursing · 2026Article
- Validation of a novel prognostic staging system for breast cancer incorporating age at diagnosis.Breast cancer research and treatment · 2026Article
- LODDS-based nomogram for breast cancer-specific survival in surgically treated breast cancer in young patients.Biomolecules & biomedicine · 2026Article
- Introduction and impact of the young breast cancer in China consensus.Cancer biology & medicine · 2025Article
- Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women.Annals of medicine · 2025Article
- Under-recognized risk factors and low perceived breast cancer risk among rural women in South-central China: A multisite cross-sectional study.Asia-Pacific journal of oncology nursing · 2025Article
- Latent profiles of ambivalence over emotional expression in young breast cancer patients: A cross-sectional study.International journal of nursing sciences · 2025Article
- Predictive markers of rapid disease progression and chemotherapy resistance in triple-negative breast cancer patients following postoperative adjuvant therapy.Scientific reports · 2025Article
- Extratumoral signs on mammography as a novel prognostic indicator for breast cancer: evidence from malignant nonspiculate and noncalcified masses.American journal of translational research · 2025Article
- Prognostic nomograms for young breast cancer: A retrospective study based on the SEER and METABRIC databases.Cancer innovation · 2024Review
- Tumour biology and survival outcomes in young women with breast cancer: single-centre retrospective analysis.BJS open · 2024Article
- Association of immune inflammatory biomarkers with pathological complete response and clinical prognosis in young breast cancer patients undergoing neoadjuvant chemotherapy.Frontiers in oncology · 2024Article
- Landscape of young breast cancer under 35 years in China over the past decades: a multicentre retrospective cohort study (YBCC-Catts study).EClinicalMedicine · 2023Article
- Epidemiology and clinicopathologic features of breast cancer in China and the United States.Translational cancer research · 2023Article
- Review
- Comparing the Biology of Young versus Old Age Estrogen-Receptor-Positive Breast Cancer through Gene and Protein Expression Analyses.Biomedicines · 2023Article
- Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Our understanding of breast cancer in very young women (≤35 years old) remains limited. We aimed to assess the clinicopathological characteristics, molecular subtype, and treatment distribution and prognosis of these young patients compared with patients over 35 years. Methods: We retrospectively analyzed non-metastatic female breast cancer cases treated at three Chinese academic hospitals between January 1, 2008, and December 31, 2018. Local recurrence-free survival (LRFS), disease-free survival (DFS), and overall survival (OS) were compared between different age groups and stratified with distinct molecular subtypes. Results: A total of 11,671 women were eligible for the final analyses, and 1,207 women (10.3%) were ≤35 years at disease onset. Very young breast cancer women were more likely to be single or childless, have higher-grade disease, have more probability of lymphovascular invasion (LVI) in tumor and triple-negative subtype, and be treated by lumpectomy, chemotherapy especially more anthracycline- and paclitaxel-based chemotherapy, endocrine therapy plus ovarian function suppression (OFS), anti-HER2 therapy, and/or radiotherapy than older women ( Conclusion: Our study demonstrated that very young women with breast cancer had higher-grade tumors, more probability of LVI in tumor, and more triple-negative subtype, when compared with older patients. They had less favorable survival outcomes, especially for patients with the HR+/HER2- subtype.
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