ArticleFrontiers in oncology2022
Treatment Modality for Stage IB Peripheral Non-Small Cell Lung Cancer With Visceral Pleural Invasion and ≤3 cm in Size.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Could less be enough: sublobar resection vs lobectomy for clinical stage IA non-small cell lung cancer patients with visceral pleural invasion or spread through air spaces.International journal of surgery (London, England) · 2025Pooled it
- Prognostic Impact of Visceral Pleural Invasion in Node-Negative Non-Small Cell Lung Cancer with Tumors ≤ 3 cm.Cancers · 2026Article
- Optimizing surgical decision-making for lung adenocarcinoma by preoperatively identifying pathological high-risk factors: retrospective development and prospective validation of a deep learning model.International journal of surgery (London, England) · 2026Article
- CT-based nomogram for estimating visceral pleural invasion in solid pulmonary adenocarcinoma nodules with pleural contact: a retrospective single-center study.BMC medical imaging · 2026Article
- Contrast-enhanced CT-based radiomics for predicting visceral pleural invasion in early-stage non-small cell lung cancer.Insights into imaging · 2026Article
- Comparison of segmentectomy and lobectomy for non-small cell lung cancer with visceral pleural invasion.Journal of cardiothoracic surgery · 2025Article
- Impact of Spread Through Air Spaces (STAS) on Recurrence and Surgical Trends in Stage I Non-Small Cell Lung Cancer: A Real-World Cohort Study.The Kaohsiung journal of medical sciences · 2025Article
- Prognostic significance of tumor spread through air spaces and lymphovascular invasion in stage I non-small cell lung cancer: implications for adjuvant chemotherapy.World journal of surgical oncology · 2025Article
- Article
- Comparison of Wedge Resection and Anatomical Lung Resection in Elderly Patients With Early-Stage Nonsmall Cell Lung Cancer With Visceral Pleural Invasion: A Population-Based Study.Thoracic cancer · 2025Article
- Development and validation of a nomogram for predicting visceral pleural invasion in patients with early-stage non-small cell lung cancer.Translational lung cancer research · 2024Article
- Baseline computed tomography imaging findings could assist in early diagnosis of visceral pleural invasion for newly discovered early subpleural non-small cell lung cancer: T1 or T2.Journal of thoracic disease · 2024Article
- [Selection of postoperative adjuvant therapy for patients with stage IB lung adenocarcinoma: analysis of 653 cases].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Impact of adjuvant chemotherapy on patients with stage IB non-small cell lung cancer with visceral pleural invasion.Journal of thoracic disease · 2024Article
- A narrative review on perioperative systemic therapy in non-small cell lung cancer.Exploration of targeted anti-tumor therapy · 2024Review
- Diagnosis, treatment, and prognosis of stage IB non-small cell lung cancer with visceral pleural invasion.Frontiers in oncology · 2023Review
- Risk analysis of visceral pleural invasion in malignant solitary pulmonary nodules that appear touching the pleural surface.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To compare the survival difference among lobectomy, segmentectomy, and wedge resection and investigate the role of adjuvant chemotherapy for early-stage small-sized non-small cell lung cancer (NSCLC) with visceral pleural invasion (VPI). Methods: Patients diagnosed with stage IB peripheral NSCLC with VPI and ≤3 cm in size in the Surveillance, Epidemiology, and End Results database between 2004 and 2015 were included, and the pleural layer (PL) invasion status was identified to recognize the tumors with VPI, including PL1 and PL2. We conducted Cox proportional hazards model in multivariable analysis and subgroup analysis Results: A total of 1,993 patients were included, all of whom received surgery, and the median follow-up was 33 months (range, 1-83 months). In multivariable analysis, age, gender, histology, pathological grade, lymph node examination, surgical approaches, and radiotherapy were independent prognostic factors for overall survival (OS). Lobectomy was superior to sublobar resection [hazard ratio (HR) = 1.41; 95% CI, 1.08-1.83], and wedge resection was associated with impaired survival compared to lobectomy (HR = 1.64; 95% CI, 1.22-2.20) in PSM analyses. In subgroup analysis, lobectomy was superior to sublobar resection among those aged <70 years (HR = 1.81; 95% CI, 1.13-2.90), female (HR = 1.75; 95% CI, 1.21-2.53), and 1-20 mm in size (HR = 1.61; 95% CI, 1.11-2.33). No survival benefit was observed for adjuvant chemotherapy. Conclusions: Lobectomy was superior to wedge resection and comparable with segmentectomy for stage IB NSCLC (≤3 cm) with VPI, and adjuvant chemotherapy could not benefit these patients, even in those with sublobar resection. The preferred surgical procedure remains to be studied in prospective controlled trials.
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