Evidence map›Paper›PMID 35280575›Full record

ArticleSaudi journal of biological sciences2022

Comparative assessment of the cell-surface antigens and gene expression profiles of the gingival tissue biomarkers in subjects with fixed functional and removable functional orthodontic appliances.

Hosam Ali Baeshen, Fahad F Alsulaimani, Wael Awadh, Maram Ahmed Ageeli, Shahabe Saquib Abullais, Nabeeh Abdullah Alqahtani, Mohammad Y Alshahrani, Jagadish Hosmani, Shankargouda Patil

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Impact of Root Canal Filling Quality on Periapical Status and Root Resorption in Orthodontically Treated Teeth: A Retrospective Radiographic Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hosam Ali BaeshenDepartment of Orthodontics, Faculty of Dentistry, King Abduaziz University, Jeddah 21589, Saudi Arabia.
Fahad F AlsulaimaniDepartment of Orthodontics, Faculty of Dentistry, King Abduaziz University, Jeddah 21589, Saudi Arabia.
Wael AwadhDivision of Orthodontics, Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Maram Ahmed AgeeliCollege of Dentistry, Jazan University, Jazan, Saudi Arabia.
Shahabe Saquib AbullaisPeriodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Nabeeh Abdullah AlqahtaniPeriodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Mohammad Y AlshahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha 9088, Saudi Arabia.
Jagadish HosmaniOral Pathology Division, Department of Dental Sciences, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Shankargouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
King Khalid University · SAJazan University · SAKing Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to examine the cellular components of the gingiva during orthodontic treatment with fixed and removable appliances. The cellular and molecular cues of pathologies of the gingival tissue associated with the use of different orthodontic appliances could be studied. Materials and methods: Tissue samples of gingiva were received from healthy patients undergoing gingivectomy for aesthetic purpose and from patients with fixed and removable functional orthodontic appliances undergoing gingivectomy for gingival overgrowth. The collected samples were stored in a sterile container with phosphate-buffered saline and to carry out further processes it was transported to the laboratory. Results: Cells positive for ECAD and NCAD were found to be increased in fixed appliances where as CD90 and CD105 positive cells showed no significant difference in all the three groups. CD24 and CD146 positive cells were increased significantly in removable and fixed than normal whereas CD133 positive cells were decreased in removable and fixed than normal. CD44 positive cells showed no noticeable change in all three groups. The gene expression levels of KRT5, SOX2, NANOG, and CXCL5 were found to be significantly increased in removable and fixed appliance groups. However, KRT8, CXCL10, and TIMP1 were increased only in fixed appliance group but CXCL10 showed decreased expression in removable appliance group. KRT6A, MYC, and MMP9 were decreased in fixed appliance group whereas MYC and MMP9 were increased in removable appliance group. KRT6A, KRT8, and TIMP1 showed no significant difference in removable appliance group. Conclusion: This study demonstrated essential roles of various genes, showing their contribution in regulating cell proliferation and migration in both the removable and fixed functional appliances.

Indexed as

BiomarkersCell-surface antigensFixed functional appliancesGene expressionRemovable functional appliances

Identifiers

PMID35280575
PMCPMC8913387
OpenAlexW3211169414

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.