Evidence map›Paper›PMID 35280499›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2022

Compositional Alterations of Gut Microbiota in Patients with Diabetic Kidney Disease and Type 2 Diabetes Mellitus.

Xin He, Jiping Sun, Chao Liu, Xiaoyang Yu, Huixian Li, Wenjing Zhang, Yan Li, Yingzhou Geng, Zhigang Wang

Open access · goldAbstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Microbiota-gut-kidney axis in health and renal disease.International journal of biological sciences · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xin HeDialysis Department of Nephrology Hospital, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Jiping SunDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Chao LiuDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Xiaoyang YuDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Huixian LiDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Wenjing ZhangDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Yan LiDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Yingzhou GengDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Zhigang WangDepartment of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Emerging evidence has revealed that gut microbiota plays a pivotal role in the pathogenesis of type 2 diabetes mellitus (T Methods: We carried out metagenomic sequencing in fecal samples of 10 DKD patients (DKD group) and 10 T Results: The gut microbial community of the DKD group was significantly different from that of the non-DKD group, characterized by a marked increase in phylum Proteobacteria, genus Conclusion: Our findings provided evidence for alterations in the composition and function of gut microbiota in patients with DKD versus the non-DKD group. These data may contribute to a more comprehensive understanding of the pathological mechanisms of DKD.

Indexed as

diabetic kidney diseasegut microbiotametagenomicstype 2 diabetes mellitus

Identifiers

PMID35280499
PMCPMC8911313
OpenAlexW4220737230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.