Evidence map›Paper›PMID 35280337›Full record

ArticlePrenatal diagnosis2021

Twin chorionicity and zygosity both vary with maternal age.

Amanda Yeaton-Massey, Teresa N Sparks, Mary E Norton, Laura Jelliffe-Pawlowski, Robert J Currier

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PubMed Full text at PMC Publisher
In one paragraph

Article in Prenatal diagnosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amanda Yeaton-MasseyObstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA.
Teresa N SparksObstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA.
Mary E NortonObstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA.
Laura Jelliffe-PawlowskiPreterm Birth Initiative - California, University of California San Francisco School of Medicine, San Francisco, CA.
Robert J CurrierDepartment of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA.

Funding

WOMEN'S REPRODUCTIVE HEALTH RESEARCH CENTERK12HD001262 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Andrea Vashti Jackson · 1998 to 2026
$9.3M
NICHD NIH HHS K12 HD001262
6 · The paper itself

Abstract

Objective: To determine the ratio of dichorionic (DC) to monochorionic (MC) twins by maternal age. Methods: We reviewed all twin pregnancies undergoing first trimester screening (FTS) with nuchal translucency from April 2009 to December 2012 with sonographic determination of chorionicity. Cases were linked to newborn screening (NBS) results and zygosity estimated based on rates of fetal sex discordance. The ratio of DC to MC placentation by maternal age was calculated. Results: We identified 11,351 twin pregnancies with FTS and documented chorionicity. Among these, 7,861 (64.2%) had linked data on FTS and NBS to allow estimation of zygosity based on neonatal sex. Of these, 1,464 (18.6%) were MC and 6,406 (81.4%) DC. The MC twin rate remained constant while the DC twin rate increased with maternal age until 40y. At < 20y, 55% of twin pregnancies were monozygotic (MZ), as compared to 29% at ≥ 40y. Of MZ twins, 38% were DC at < 20y, while 53% were DC at ≥ 40y. Conclusions: Our data suggest a relationship of both zygosity and chorionicity with maternal age. DZ twinning increased with maternal age, while among MZ twins, the proportion that were DC also increased with maternal age.

Indexed as

ChorionTwins, DizygoticFemaleGestational AgeHumansInfant, NewbornMaternal AgePregnancyPregnancy, TwinTwins, Monozygoticchorionicitymaternal agetwinszygosity

Identifiers

PMID35280337
PMCPMC8916645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.