Evidence map›Paper›PMID 35280335›Full record

ArticleInternational journal of nanomedicine2022

Screening of Chitosan Derivatives-Carbon Dots Based on Antibacterial Activity and Application in Anti-

Dan Zhao, Rui Zhang, Xuemei Liu, Xiaoyun Li, Mengyu Xu, Xianju Huang, Xincai Xiao

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Antibacterial carbon dots.Materials today. Bio · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Newly designed nanoparticle-drug delivery systems againstInternational journal of clinical and experimental pathology · 2024
    Review
  12. Review
  13. Recent progress in carbon dots for anti-pathogen applications in oral cavity.Frontiers in cellular and infection microbiology · 2023
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dan ZhaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.ORCID 0000-0002-9500-7410
Rui ZhangSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.ORCID 0000-0003-0094-5445
Xuemei LiuSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.
Xiaoyun LiSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.ORCID 0000-0002-2373-6374
Mengyu XuSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.ORCID 0000-0002-4850-457X
Xianju HuangSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.ORCID 0000-0002-0218-6983
Xincai XiaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.
South Central Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pathogenic bacteria, especially the ones with highly organized, systematic aggregating bacteria biofilm, would cause great harm to human health. The development of highly efficient antibacterial and antibiofilm functional fluorescent nanomaterial would be of great significance. Methods: This paper reports the preparation of a series of antibacterial functional carbon dots (CDs) with chitosan (CS) and its derivatives as raw materials through one-step route, and the impact of various experiment parameters upon the optical properties and the antibacterial abilities have been explored, including the structures of the raw materials, excipients, and solvents. Results: The CDs prepared by quaternary ammonium salt of chitosan (QCS) and ethylenediamine (EDA) exhibit multiple antibacterial effects through membrane breaking, DNA and protein destroying, and the production of singlet oxygen. The CDs showed excellent broad-spectrum inhibitory activity against a variety of bacteria (Gram-positive and negative bacteria), in particular, to the biofilm of Conclusion: This paper explored the preparation and application of functional CDs, which can be used as the visual probe and therapeutic agents in the treatment of infections caused by bacteria and biofilm.

Indexed as

ChitosanStaphylococcus aureusAnti-Bacterial AgentsBiofilmsCarbonHumansAnti-Bacterial AgentsCarbonChitosanantibacterial activityantibacterial mechanismanti-biofilmbacterial imagingcarbon dots

Identifiers

PMID35280335
PMCPMC8904944
OpenAlexW4214946171

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.